 |
 |
|
|
| 19/11/2021 | 22:00 | 12 de Octubre de Itauguá | - | Guaireña FC | 0:0 (0:0) | |
| 20/11/2021 | 22:45 | Guaraní | - | River Plate | 2:1 (0:0) | |
| 22:45 | Sportivo Luqueño | - | Libertad | 2:2 (2:1) | ||
| 21/11/2021 | 21:00 | Sol de América | - | Club Olimpia | 1:0 (0:0) | |
| 23:15 | Club Nacional | - | Cerro Porteño | 1:5 (1:2) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Guaraní | 16 | 10 | 4 | 2 | 36:16 | 20 | 34 |
| 2 |
|
Cerro Porteño | 16 | 10 | 4 | 2 | 24:6 | 18 | 34 |
| 3 |
|
Sol de América | 16 | 7 | 4 | 5 | 19:21 | -2 | 25 |
| 4 |
|
Libertad | 16 | 5 | 6 | 5 | 24:19 | 5 | 21 |
| 5 |
|
Club Nacional | 16 | 4 | 8 | 4 | 16:19 | -3 | 20 |
| 6 |
|
Sportivo Luqueño | 16 | 5 | 5 | 6 | 16:26 | -10 | 20 |
| 7 |
|
12 de Octubre de Itauguá | 16 | 4 | 6 | 6 | 17:21 | -4 | 18 |
| 8 |
|
River Plate | 16 | 4 | 4 | 8 | 15:23 | -8 | 16 |
| 9 |
|
Club Olimpia | 16 | 5 | 0 | 11 | 19:25 | -6 | 15 |
| 10 |
|
Guaireña FC | 16 | 3 | 5 | 8 | 10:20 | -10 | 14 |
| 11 |
|
Deportivo Recoleta | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Copa Libertadores |
