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| 1st(1st leg) | Sporting CP | - | FC Porto | 1:2 (0:0) | ||
| 2nd (2nd leg) | FC Porto | - | Sporting CP | 1:0 (0:0) | ||
| 1st(1st leg): 02/03/2022 20:45 | 2nd (2nd leg): 21/04/2022 20:15 | Winner: FC Porto | ||||
| 1st(1st leg) | CD Tondela | - | CD Mafra | 3:0 (1:0) | ||
| 2nd (2nd leg) | CD Mafra | - | CD Tondela | 1:1 (1:0) | ||
| 1st(1st leg): 03/03/2022 20:15 | 2nd (2nd leg): 20/04/2022 20:15 | Winner: CD Tondela | ||||
