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| 1st(1st leg) | FC Penafiel | - | Vitória Setúbal | 2:0 (1:0) | ||
| 2nd (2nd leg) | Vitória Setúbal | - | FC Penafiel | 1:4 (2:0, 3:1) pso | ||
| 1st(1st leg): 09/10/2010 17:00 | 2nd (2nd leg): 10/11/2010 18:00 | Winner: FC Penafiel | ||||
| 1st(1st leg) | FC Arouca | - | Académica de Coimbra | 2:2 (0:0) | ||
| 2nd (2nd leg) | Académica de Coimbra | - | FC Arouca | 2:4 (1:0, 1:1) pso | ||
| 1st(1st leg): 10/10/2010 16:00 | 2nd (2nd leg): 10/11/2010 16:00 | Winner: FC Arouca | ||||
| 1st(1st leg) | CD Fátima | - | SC Beira-Mar | 1:1 (0:1) | ||
| 2nd (2nd leg) | SC Beira-Mar | - | CD Fátima | 4:1 (0:1) | ||
| 1st(1st leg): 10/10/2010 16:00 | 2nd (2nd leg): 17/11/2010 16:00 | Winner: SC Beira-Mar | ||||
| 1st(1st leg) | Leixões SC | - | Paços de Ferreira | 1:1 (1:0) | ||
| 2nd (2nd leg) | Paços de Ferreira | - | Leixões SC | 2:1 (1:1) | ||
| 1st(1st leg): 10/10/2010 17:00 | 2nd (2nd leg): 10/11/2010 19:00 | Winner: Paços de Ferreira | ||||
| 1st(1st leg) | GD Estoril | - | Rio Ave FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Rio Ave FC | - | GD Estoril | 3:4 (0:0, 1:1) pso | ||
| 1st(1st leg): 20/10/2010 17:00 | 2nd (2nd leg): 10/11/2010 15:00 | Winner: GD Estoril | ||||
| 1st(1st leg) | Gil Vicente | - | União Leiria | 3:2 (3:1) | ||
| 2nd (2nd leg) | União Leiria | - | Gil Vicente | 1:1 (0:1) | ||
| 1st(1st leg): 20/10/2010 18:00 | 2nd (2nd leg): 20/11/2010 17:00 | Winner: Gil Vicente | ||||
| 1st(1st leg) | UD Oliveirense | - | SC Olhanense | 1:0 (0:0) | ||
| 2nd (2nd leg) | SC Olhanense | - | UD Oliveirense | 4:1 (2:0) | ||
| 1st(1st leg): 27/10/2010 15:00 | 2nd (2nd leg): 10/11/2010 16:00 | Winner: SC Olhanense | ||||
| 1st(1st leg) | CD Aves | - | Portimonense SC | 3:2 (1:1) | ||
| 2nd (2nd leg) | Portimonense SC | - | CD Aves | 1:1 (1:0) | ||
| 1st(1st leg): 28/10/2010 18:30 | 2nd (2nd leg): 10/11/2010 18:00 | Winner: CD Aves | ||||
