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| 17/12/2021 | 18:00 | FC-Astoria Walldorf | - | VfB Stuttgart II | 1:1 (1:1) | |
| 18:00 | 1899 Hoffenheim II | - | FC 08 Homburg | 2:1 (2:0) | ||
| 18/12/2021 | 13:00 | Bahlinger SC | - | VfR Aalen | 2:2 (0:2) | |
| 13:00 | FK Pirmasens | - | FC Gießen | 2:1 (0:0) | ||
| 13:00 | 1. FSV Mainz 05 II | - | SG Sonnenhof Großaspach | 2:0 (0:0) | ||
| 13:00 | Hessen Kassel | - | FSV Frankfurt | 0:0 (0:0) | ||
| 13:00 | Rot-Weiß Koblenz | - | SV 07 Elversberg | 0:2 (0:1) | ||
| 13:00 | SSV Ulm 1846 | - | Kickers Offenbach | 1:0 (1:0) | ||
| 13:00 | TSV Schott Mainz | - | TSV Steinbach Haiger | 3:3 (1:0) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSV Ulm 1846 | 22 | 14 | 4 | 4 | 38:22 | 16 | 46 |
| 2 |
|
1. FSV Mainz 05 II | 22 | 15 | 1 | 6 | 37:25 | 12 | 46 |
| 3 |
|
Kickers Offenbach | 21 | 14 | 2 | 5 | 39:14 | 25 | 44 |
| 4 |
|
SV 07 Elversberg | 21 | 12 | 5 | 4 | 48:21 | 27 | 41 |
| 5 |
|
TSV Steinbach Haiger | 22 | 11 | 7 | 4 | 37:27 | 10 | 40 |
| 6 |
|
FC 08 Homburg | 22 | 10 | 5 | 7 | 30:30 | 0 | 35 |
| 7 |
|
Bahlinger SC | 21 | 10 | 3 | 8 | 22:23 | -1 | 33 |
| 8 |
|
Hessen Kassel | 22 | 8 | 6 | 8 | 29:24 | 5 | 30 |
| 9 |
|
VfR Aalen | 22 | 9 | 3 | 10 | 35:42 | -7 | 30 |
| 10 |
|
TSG Balingen | 21 | 8 | 3 | 10 | 30:38 | -8 | 27 |
| 11 |
|
1899 Hoffenheim II | 22 | 7 | 5 | 10 | 33:34 | -1 | 26 |
| 12 |
|
FC-Astoria Walldorf | 22 | 7 | 5 | 10 | 34:41 | -7 | 26 |
| 13 |
|
Rot-Weiß Koblenz | 22 | 6 | 7 | 9 | 24:30 | -6 | 25 |
| 14 |
|
VfB Stuttgart II | 22 | 6 | 6 | 10 | 31:33 | -2 | 24 |
| 15 |
|
FK Pirmasens | 22 | 6 | 6 | 10 | 21:32 | -11 | 24 |
| 16 |
|
FSV Frankfurt | 22 | 5 | 7 | 10 | 26:31 | -5 | 22 |
| 17 |
|
FC Gießen | 22 | 6 | 4 | 12 | 20:29 | -9 | 22 |
| 18 |
|
SG Sonnenhof Großaspach | 22 | 5 | 5 | 12 | 26:48 | -22 | 20 |
| 19 |
|
TSV Schott Mainz | 22 | 4 | 4 | 14 | 21:37 | -16 | 16 |
| Promotion | |
| Relegation |
