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| 24/08/2021 | 17:00 | Bahlinger SC | - | TSG Balingen | 2:1 (1:0) | |
| 18:00 | FC-Astoria Walldorf | - | SG Sonnenhof Großaspach | 0:3 (0:2) | ||
| 18:00 | FK Pirmasens | - | VfR Aalen | 1:0 (0:0) | ||
| 18:00 | Rot-Weiß Koblenz | - | FC 08 Homburg | 4:0 (2:0) | ||
| 18:00 | SSV Ulm 1846 | - | SV 07 Elversberg | 4:2 (3:1) | ||
| 18:00 | 1899 Hoffenheim II | - | FSV Frankfurt | 3:1 (2:0) | ||
| 18:00 | TSV Schott Mainz | - | FC Gießen | 1:0 (0:0) | ||
| 25/08/2021 | 13:00 | 1. FSV Mainz 05 II | - | TSV Steinbach Haiger | 2:1 (1:0) | |
| 17:00 | Hessen Kassel | - | VfB Stuttgart II | 3:2 (1:1) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FSV Mainz 05 II | 3 | 3 | 0 | 0 | 6:2 | 4 | 9 |
| 2 |
|
SG Sonnenhof Großaspach | 3 | 2 | 1 | 0 | 8:2 | 6 | 7 |
| 3 |
|
1899 Hoffenheim II | 3 | 2 | 1 | 0 | 7:3 | 4 | 7 |
| 4 |
|
FK Pirmasens | 3 | 2 | 1 | 0 | 3:1 | 2 | 7 |
| 5 |
|
Rot-Weiß Koblenz | 3 | 2 | 0 | 1 | 5:3 | 2 | 6 |
| 6 |
|
Kickers Offenbach | 2 | 2 | 0 | 0 | 3:1 | 2 | 6 |
| 7 |
|
SSV Ulm 1846 | 3 | 1 | 2 | 0 | 10:8 | 2 | 5 |
| 8 |
|
Bahlinger SC | 2 | 1 | 1 | 0 | 2:1 | 1 | 4 |
| 9 |
|
TSV Schott Mainz | 3 | 1 | 1 | 1 | 2:3 | -1 | 4 |
| 10 |
|
Hessen Kassel | 3 | 1 | 1 | 1 | 5:7 | -2 | 4 |
| 11 |
|
VfB Stuttgart II | 3 | 1 | 0 | 2 | 6:6 | 0 | 3 |
| 12 |
|
VfR Aalen | 3 | 1 | 0 | 2 | 4:5 | -1 | 3 |
| 13 |
|
FC Gießen | 3 | 1 | 0 | 2 | 1:2 | -1 | 3 |
| 14 |
|
TSV Steinbach Haiger | 3 | 0 | 2 | 1 | 2:3 | -1 | 2 |
| 15 |
|
TSG Balingen | 3 | 0 | 1 | 2 | 2:4 | -2 | 1 |
| 16 |
|
FSV Frankfurt | 3 | 0 | 1 | 2 | 4:7 | -3 | 1 |
| 17 |
|
FC-Astoria Walldorf | 3 | 0 | 1 | 2 | 0:4 | -4 | 1 |
| 18 |
|
FC 08 Homburg | 3 | 0 | 1 | 2 | 3:8 | -5 | 1 |
| 19 |
|
SV 07 Elversberg | 2 | 0 | 0 | 2 | 3:6 | -3 | 0 |
| Promotion | |
| Relegation |
