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| 24/10/2020 | 13:00 | Alemannia Aachen | - | SV Bergisch Gladbach 09 | 3:2 (1:0) | |
| 13:00 | Bonner SC | - | Preußen Münster | 1:2 (0:1) | ||
| 13:00 | Rot Weiss Ahlen | - | SV Lippstadt 08 | 1:1 (0:0) | ||
| 13:00 | Sportfreunde Lotte | - | FC Schalke 04 II | 0:0 (0:0) | ||
| 14:30 | Rot-Weiss Essen | - | Rot-Weiß Oberhausen | 3:0 (1:0) | ||
| 15:00 | 1. FC Köln II | - | SV Rödinghausen | 3:1 (2:1) | ||
| 25/10/2020 | 13:00 | FC Wegberg-Beeck | - | VfB Homberg | 1:0 (0:0) | |
| 02/12/2020 | 17:30 | SC Wiedenbrück | - | Bor. Mönchengladbach II | 0:4 (0:1) | |
| 18:30 | Wuppertaler SV | - | SV 19 Straelen | 0:3 (0:1) | ||
| 22/12/2020 | 16:30 | Borussia Dortmund II | - | Fortuna Düsseldorf II | 1:1 (1:1) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Borussia Dortmund II | 10 | 7 | 3 | 0 | 25:7 | 18 | 24 |
| 2 |
|
Rot-Weiss Essen | 10 | 7 | 3 | 0 | 18:5 | 13 | 24 |
| 3 |
|
Preußen Münster | 11 | 7 | 2 | 2 | 19:9 | 10 | 23 |
| 4 |
|
Fortuna Köln | 10 | 6 | 3 | 1 | 22:11 | 11 | 21 |
| 5 |
|
Fortuna Düsseldorf II | 10 | 5 | 4 | 1 | 20:5 | 15 | 19 |
| 6 |
|
Bor. Mönchengladbach II | 11 | 5 | 2 | 4 | 21:14 | 7 | 17 |
| 7 |
|
1. FC Köln II | 10 | 4 | 4 | 2 | 14:10 | 4 | 16 |
| 8 |
|
FC Schalke 04 II | 11 | 4 | 4 | 3 | 11:7 | 4 | 16 |
| 9 |
|
SV 19 Straelen | 11 | 4 | 4 | 3 | 16:14 | 2 | 16 |
| 10 |
|
Alemannia Aachen | 11 | 4 | 3 | 4 | 8:9 | -1 | 15 |
| 11 |
|
SV Rödinghausen | 11 | 3 | 5 | 3 | 11:10 | 1 | 14 |
| 12 |
|
SV Bergisch Gladbach 09 | 11 | 3 | 3 | 5 | 9:14 | -5 | 12 |
| 13 |
|
Wuppertaler SV | 11 | 3 | 3 | 5 | 12:19 | -7 | 12 |
| 14 |
|
SC Wiedenbrück | 10 | 2 | 5 | 3 | 14:19 | -5 | 11 |
| 15 |
|
Rot-Weiß Oberhausen | 11 | 2 | 4 | 5 | 9:18 | -9 | 10 |
| 16 |
|
FC Wegberg-Beeck | 10 | 2 | 3 | 5 | 10:14 | -4 | 9 |
| 17 |
|
SV Lippstadt 08 | 10 | 1 | 6 | 3 | 8:14 | -6 | 9 |
| 18 |
|
Sportfreunde Lotte | 10 | 2 | 3 | 5 | 11:23 | -12 | 9 |
| 19 |
|
Bonner SC | 10 | 2 | 2 | 6 | 10:18 | -8 | 8 |
| 20 |
|
Rot Weiss Ahlen | 10 | 1 | 3 | 6 | 12:23 | -11 | 6 |
| 21 |
|
VfB Homberg | 11 | 1 | 1 | 9 | 7:24 | -17 | 4 |
| Promotion | |
| Relegation |
