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| 20/08/2021 | 18:30 | 1. FC Köln II | - | SV Lippstadt 08 | 3:1 (2:1) | |
| 18:30 | Rot-Weiss Essen | - | SV 19 Straelen | 1:4 (0:0) | ||
| 21/08/2021 | 13:00 | Rot Weiss Ahlen | - | Wuppertaler SV | 0:0 (0:0) | |
| 13:00 | SV Rödinghausen | - | Fortuna Köln | 1:4 (0:3) | ||
| 13:00 | FC Wegberg-Beeck | - | Fortuna Düsseldorf II | 1:2 (0:0) | ||
| 13:00 | Sportfreunde Lotte | - | VfB Homberg | 2:0 (1:0) | ||
| 13:00 | Alemannia Aachen | - | FC Schalke 04 II | 1:1 (0:0) | ||
| 13:00 | SC Wiedenbrück | - | Rot-Weiß Oberhausen | 1:0 (1:0) | ||
| 13:00 | KFC Uerdingen 05 | - | Bonner SC | 1:3 (0:2) | ||
| 15:00 | Bor. Mönchengladbach II | - | Preußen Münster | 1:2 (0:1) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Fortuna Köln | 2 | 2 | 0 | 0 | 6:1 | 5 | 6 |
| 2 |
|
SV 19 Straelen | 2 | 2 | 0 | 0 | 7:3 | 4 | 6 |
| 3 |
|
1. FC Köln II | 2 | 2 | 0 | 0 | 5:2 | 3 | 6 |
| 4 |
|
Fortuna Düsseldorf II | 2 | 2 | 0 | 0 | 4:2 | 2 | 6 |
|
Preußen Münster | 2 | 2 | 0 | 0 | 4:2 | 2 | 6 | |
| 6 |
|
Wuppertaler SV | 2 | 1 | 1 | 0 | 2:0 | 2 | 4 |
| 7 |
|
Rot-Weiß Oberhausen | 2 | 1 | 0 | 1 | 6:1 | 5 | 3 |
| 8 |
|
Bor. Mönchengladbach II | 2 | 1 | 0 | 1 | 3:2 | 1 | 3 |
|
Sportfreunde Lotte | 2 | 1 | 0 | 1 | 3:2 | 1 | 3 | |
| 10 |
|
Rot-Weiss Essen | 2 | 1 | 0 | 1 | 4:4 | 0 | 3 |
| 11 |
|
SC Wiedenbrück | 2 | 1 | 0 | 1 | 1:1 | 0 | 3 |
| 12 |
|
Bonner SC | 2 | 1 | 0 | 1 | 3:4 | -1 | 3 |
| 13 |
|
SV Lippstadt 08 | 2 | 1 | 0 | 1 | 2:3 | -1 | 3 |
| 14 |
|
Alemannia Aachen | 2 | 0 | 1 | 1 | 2:3 | -1 | 1 |
|
FC Schalke 04 II | 2 | 0 | 1 | 1 | 2:3 | -1 | 1 | |
|
Rot Weiss Ahlen | 2 | 0 | 1 | 1 | 2:3 | -1 | 1 | |
| 17 |
|
FC Wegberg-Beeck | 2 | 0 | 0 | 2 | 1:4 | -3 | 0 |
| 18 |
|
VfB Homberg | 2 | 0 | 0 | 2 | 0:4 | -4 | 0 |
| 19 |
|
SV Rödinghausen | 2 | 0 | 0 | 2 | 1:6 | -5 | 0 |
| 20 |
|
KFC Uerdingen 05 | 2 | 0 | 0 | 2 | 1:9 | -8 | 0 |
| Promotion | |
| Relegation |
