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| 24/08/2021 | 18:30 | Bonner SC | - | SV 19 Straelen | 1:3 (1:0) | |
| 25/08/2021 | 13:00 | FC Schalke 04 II | - | Bor. Mönchengladbach II | 1:0 (0:0) | |
| 17:00 | SV Lippstadt 08 | - | Alemannia Aachen | 2:0 (1:0) | ||
| 17:00 | Fortuna Düsseldorf II | - | SV Rödinghausen | 3:1 (2:1) | ||
| 18:00 | Wuppertaler SV | - | Rot-Weiss Essen | 0:1 (0:1) | ||
| 18:30 | Preußen Münster | - | Sportfreunde Lotte | 2:0 (2:0) | ||
| 18:30 | VfB Homberg | - | FC Wegberg-Beeck | 1:1 (1:0) | ||
| 18:30 | Fortuna Köln | - | Rot Weiss Ahlen | 1:1 (1:1) | ||
| 18:30 | KFC Uerdingen 05 | - | SC Wiedenbrück | 2:3 (1:0) | ||
| 18:30 | Rot-Weiß Oberhausen | - | 1. FC Köln II | 1:0 (0:0) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SV 19 Straelen | 3 | 3 | 0 | 0 | 10:4 | 6 | 9 |
| 2 |
|
Fortuna Düsseldorf II | 3 | 3 | 0 | 0 | 7:3 | 4 | 9 |
| 3 |
|
Preußen Münster | 3 | 3 | 0 | 0 | 6:2 | 4 | 9 |
| 4 |
|
Fortuna Köln | 3 | 2 | 1 | 0 | 7:2 | 5 | 7 |
| 5 |
|
Rot-Weiß Oberhausen | 3 | 2 | 0 | 1 | 7:1 | 6 | 6 |
| 6 |
|
1. FC Köln II | 3 | 2 | 0 | 1 | 5:3 | 2 | 6 |
| 7 |
|
Rot-Weiss Essen | 3 | 2 | 0 | 1 | 5:4 | 1 | 6 |
| 8 |
|
SC Wiedenbrück | 3 | 2 | 0 | 1 | 4:3 | 1 | 6 |
|
SV Lippstadt 08 | 3 | 2 | 0 | 1 | 4:3 | 1 | 6 | |
| 10 |
|
Wuppertaler SV | 3 | 1 | 1 | 1 | 2:1 | 1 | 4 |
| 11 |
|
FC Schalke 04 II | 3 | 1 | 1 | 1 | 3:3 | 0 | 4 |
| 12 |
|
Bor. Mönchengladbach II | 3 | 1 | 0 | 2 | 3:3 | 0 | 3 |
| 13 |
|
Sportfreunde Lotte | 3 | 1 | 0 | 2 | 3:4 | -1 | 3 |
| 14 |
|
Bonner SC | 3 | 1 | 0 | 2 | 4:7 | -3 | 3 |
| 15 |
|
Rot Weiss Ahlen | 3 | 0 | 2 | 1 | 3:4 | -1 | 2 |
| 16 |
|
Alemannia Aachen | 3 | 0 | 1 | 2 | 2:5 | -3 | 1 |
|
FC Wegberg-Beeck | 3 | 0 | 1 | 2 | 2:5 | -3 | 1 | |
| 18 |
|
VfB Homberg | 3 | 0 | 1 | 2 | 1:5 | -4 | 1 |
| 19 |
|
SV Rödinghausen | 3 | 0 | 0 | 3 | 2:9 | -7 | 0 |
| 20 |
|
KFC Uerdingen 05 | 3 | 0 | 0 | 3 | 3:12 | -9 | 0 |
| Promotion | |
| Relegation |
