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| 30/04/2022 | 12:00 | Chertanovo Football Academy | - | FK Krasnodar | 1:3 (0:2) | |
| 13:00 | SShOR Zenit | - | FShM Moskva | 0:1 (0:1) | ||
| 13:30 | Rubin Kazan | - | Kuban Krasnodar | 0:0 (0:0) | ||
| 14:00 | Lokomotiv Moskva | - | Spartak Moskva | 1:4 (0:1) | ||
| 15:00 | CSKA Moskva | - | Dinamo Moskva | 5:2 (2:2) | ||
| 01/05/2022 | 12:00 | FK Strogino Moskva | - | FK Saturn | 2:1 (1:0) | |
| 12:30 | FK Rostov | - | Zenit St. Petersburg | 3:1 (2:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Spartak Moskva | 23 | 17 | 3 | 3 | 61:17 | 44 | 54 |
| 2 |
|
FK Krasnodar | 23 | 16 | 4 | 3 | 57:21 | 36 | 52 |
| 3 |
|
FK Rostov | 23 | 14 | 5 | 4 | 42:21 | 21 | 47 |
| 4 |
|
Zenit St. Petersburg | 23 | 14 | 4 | 5 | 63:34 | 29 | 46 |
| 5 |
|
Chertanovo Football Academy | 23 | 13 | 3 | 7 | 53:35 | 18 | 42 |
| 6 |
|
FK Strogino Moskva | 23 | 13 | 1 | 9 | 40:32 | 8 | 40 |
| 7 |
|
Lokomotiv Moskva | 23 | 10 | 2 | 11 | 43:50 | -7 | 32 |
| 8 |
|
FK Saturn | 23 | 8 | 4 | 11 | 38:57 | -19 | 28 |
| 9 |
|
CSKA Moskva | 23 | 8 | 4 | 11 | 45:50 | -5 | 28 |
| 10 |
|
SShOR Zenit | 23 | 7 | 4 | 12 | 31:44 | -13 | 25 |
| 11 |
|
Kuban Krasnodar | 23 | 5 | 7 | 11 | 21:46 | -25 | 22 |
| 12 |
|
FShM Moskva | 23 | 3 | 5 | 15 | 26:63 | -37 | 14 |
| 13 |
|
Dinamo Moskva | 23 | 3 | 4 | 16 | 28:55 | -27 | 13 |
| 14 |
|
Rubin Kazan | 23 | 2 | 6 | 15 | 20:43 | -23 | 12 |
