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| 17/07/2010 | 15:45 | Zenit St. Petersburg | - | Sibir Novosibirsk | 2:0 (1:0) | |
| 18:00 | Dinamo Moskva | - | FK Rostov | 3:2 (2:2) | ||
| 18:00 | Spartak Moskva | - | Rubin Kazan | 0:1 (0:1) | ||
| 18/07/2010 | 13:00 | FK Tom Tomsk | - | Anzhi Makhachkala | 1:4 (0:2) | |
| 15:45 | Terek Grozny | - | FK Amkar Perm | 1:0 (1:0) | ||
| 17:30 | Lokomotiv Moskva | - | Spartak Vladikavkaz | 3:0 (2:0) | ||
| 19/07/2010 | 17:00 | Krylia Sovetov | - | CSKA Moskva | 0:1 (0:1) | |
| 17:45 | FK Saturn | - | Spartak Nalchik | 3:1 (3:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit St. Petersburg | 13 | 10 | 3 | 0 | 20:5 | 15 | 33 |
| 2 |
|
CSKA Moskva | 13 | 8 | 3 | 2 | 21:10 | 11 | 27 |
| 3 |
|
Rubin Kazan | 13 | 7 | 5 | 1 | 13:3 | 10 | 26 |
| 4 |
|
Spartak Nalchik | 13 | 6 | 4 | 3 | 17:13 | 4 | 22 |
| 5 |
|
Lokomotiv Moskva | 13 | 6 | 3 | 4 | 18:12 | 6 | 21 |
| 6 |
|
Spartak Moskva | 13 | 5 | 4 | 4 | 19:16 | 3 | 19 |
| 7 |
|
FK Rostov | 13 | 6 | 1 | 6 | 14:19 | -5 | 19 |
| 8 |
|
Dinamo Moskva | 13 | 4 | 6 | 3 | 15:13 | 2 | 18 |
| 9 |
|
FK Tom Tomsk | 13 | 5 | 3 | 5 | 16:18 | -2 | 18 |
| 10 |
|
Terek Grozny | 13 | 4 | 5 | 4 | 13:12 | 1 | 17 |
| 11 |
|
Anzhi Makhachkala | 13 | 3 | 4 | 6 | 15:16 | -1 | 13 |
| 12 |
|
FK Amkar Perm | 13 | 3 | 3 | 7 | 9:15 | -6 | 12 |
| 13 |
|
Spartak Vladikavkaz | 13 | 3 | 3 | 7 | 13:21 | -8 | 12 |
| 14 |
|
FK Saturn | 13 | 2 | 5 | 6 | 9:13 | -4 | 11 |
| 15 |
|
Sibir Novosibirsk | 13 | 2 | 2 | 9 | 17:29 | -12 | 8 |
| 16 |
|
Krylia Sovetov | 13 | 2 | 2 | 9 | 8:22 | -14 | 8 |
| Champions League | |
| Champions League Quali. | |
| Europa League | |
| Relegation |
