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| 1st(1st leg) | Santa Tecla FC | - | FAS | 0:1 (0:0) | ||
| 2nd (2nd leg) | FAS | - | Santa Tecla FC | 4:2 (0:0, 0:1) pso | ||
| 1st(1st leg): 16/05/2021 02:00 | 2nd (2nd leg): 23/05/2021 22:15 | Winner: FAS | ||||
| 1st(1st leg) | Luis Ángel Firpo | - | Alianza | 1:2 (0:1) | ||
| 2nd (2nd leg) | Alianza | - | Luis Ángel Firpo | 5:4 (0:0, 0:1) pso | ||
| 1st(1st leg): 16/05/2021 22:00 | 2nd (2nd leg): 23/05/2021 02:15 | Winner: Alianza | ||||
