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| 1st(1st leg) | SP Tre Fiori | - | SC Faetano | 1:1 (0:0) | ||
| 2nd (2nd leg) | SC Faetano | - | SP Tre Fiori | 1:1 (0:0) | ||
| 1st(1st leg): 11/05/2022 19:45 | 2nd (2nd leg): 15/05/2022 14:00 | |||||
| 1st(1st leg) | SS Virtus | - | SS Pennarossa | 0:1 (0:0) | ||
| 2nd (2nd leg) | SS Pennarossa | - | SS Virtus | 1:1 (0:1) | ||
| 1st(1st leg): 11/05/2022 19:45 | 2nd (2nd leg): 15/05/2022 14:00 | Winner: SS Pennarossa | ||||
| 1st(1st leg) | SP Tre Penne | - | AC Libertas | 2:0 (0:0) | ||
| 2nd (2nd leg) | AC Libertas | - | SP Tre Penne | 1:0 (1:0) | ||
| 1st(1st leg): 11/05/2022 19:45 | 2nd (2nd leg): 15/05/2022 14:00 | Winner: SP Tre Penne | ||||
| 1st(1st leg) | SP La Fiorita | - | FC Fiorentino | 0:1 (0:0) | ||
| 2nd (2nd leg) | FC Fiorentino | - | SP La Fiorita | 0:2 (0:1) | ||
| 1st(1st leg): 11/05/2022 19:45 | 2nd (2nd leg): 15/05/2022 14:00 | Winner: SP La Fiorita | ||||
