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| 1st(1st leg) | SP La Fiorita | - | SC Faetano | 3:0 | ||
| 2nd (2nd leg) | SC Faetano | - | SP La Fiorita | 0:1 | ||
| 1st(1st leg): 24/11/2021 19:45 | 2nd (2nd leg): 08/12/2021 19:45 | Winner: SP La Fiorita | ||||
| 1st(1st leg) | SS Pennarossa | - | SP Tre Fiori | 0:1 | ||
| 2nd (2nd leg) | SP Tre Fiori | - | SS Pennarossa | 3:1 | ||
| 1st(1st leg): 24/11/2021 19:45 | 2nd (2nd leg): 08/12/2021 19:45 | Winner: SP Tre Fiori | ||||
| 1st(1st leg) | SS Folgore/Falciano | - | SS Murata | 0:0 | ||
| 2nd (2nd leg) | SS Murata | - | SS Folgore/Falciano | 1:2 | ||
| 1st(1st leg): 24/11/2021 19:45 | 2nd (2nd leg): 08/12/2021 19:45 | Winner: SS Folgore/Falciano | ||||
| 1st(1st leg) | FC Domagnano | - | SP Tre Penne | 2:0 | ||
| 2nd (2nd leg) | SP Tre Penne | - | FC Domagnano | 2:1 | ||
| 1st(1st leg): 24/11/2021 19:45 | 2nd (2nd leg): 08/12/2021 19:45 | Winner: FC Domagnano | ||||
