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| 1st(1st leg) | BSC Young Boys | - | FC Zürich Frauen | 1:2 (1:0) | ||
| 2nd (2nd leg) | FC Zürich Frauen | - | BSC Young Boys | 7:0 (1:0) | ||
| 1st(1st leg): 07/05/2022 14:30 | 2nd (2nd leg): 14/05/2022 13:30 | Winner: FC Zürich Frauen | ||||
| 1st(1st leg) | FC Aarau | - | Servette FCCF | 0:1 (0:1) | ||
| 2nd (2nd leg) | Servette FCCF | - | FC Aarau | 4:0 (2:0) | ||
| 1st(1st leg): 07/05/2022 15:00 | 2nd (2nd leg): 14/05/2022 17:00 | Winner: Servette FCCF | ||||
| 1st(1st leg) | FC Luzern | - | Grasshopper Club Zürich | 2:5 (2:4) | ||
| 2nd (2nd leg) | Grasshopper Club Zürich | - | FC Luzern | 3:3 (1:2) | ||
| 1st(1st leg): 07/05/2022 17:00 | 2nd (2nd leg): 14/05/2022 18:00 | Winner: Grasshopper Club Zürich | ||||
| 1st(1st leg) | FC St. Gallen | - | FC Basel | 0:3 (0:0) | ||
| 2nd (2nd leg) | FC Basel | - | FC St. Gallen | 4:1 (0:1) | ||
| 1st(1st leg): 08/05/2022 15:00 | 2nd (2nd leg): 14/05/2022 17:00 | Winner: FC Basel | ||||
