1st(1st leg) Spartak Trnava - FK Senica 3:0 (1:0)
2nd (2nd leg) FK Senica - Spartak Trnava 0:4 (0:2)
1st(1st leg): 06/04/2022 18:45 2nd (2nd leg): 20/04/2022 18:30 Winner: Spartak Trnava
1st(1st leg) AS Trenčín - Slovan Bratislava 0:0 (0:0)
2nd (2nd leg) Slovan Bratislava - AS Trenčín 2:1 (2:0)
1st(1st leg): 07/04/2022 18:45 2nd (2nd leg): 19/04/2022 18:30 Winner: Slovan Bratislava