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| 04/03/2022 | 17:00 | Kocaelispor | - | Keçiörengücü | 1:0 (0:0) | |
| 05/03/2022 | 10:30 | Altınordu FK | - | BB Erzurumspor | 1:0 (1:0) | |
| 13:00 | Samsunspor | - | Menemen Belediyespor | 2:4 (2:2) | ||
| 16:00 | MKE Ankaragücü | - | Bandırmaspor | 1:0 (0:0) | ||
| 06/03/2022 | 10:30 | Adanaspor | - | Manisa FK | 2:0 (0:0) | |
| 10:30 | Boluspor | - | Bursaspor | 1:1 (1:0) | ||
| 13:00 | Tuzlaspor | - | İstanbulspor AŞ | 0:2 (0:2) | ||
| 16:00 | Eyüpspor | - | Ümraniyespor | 0:1 (0:1) | ||
| 07/03/2022 | 17:00 | Balıkesirspor | - | Denizlispor | 0:1 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 27 | 18 | 4 | 5 | 42:19 | 23 | 58 |
| 2 |
|
Ümraniyespor | 27 | 17 | 4 | 6 | 47:26 | 21 | 55 |
| 3 |
|
Bandırmaspor | 27 | 14 | 4 | 9 | 39:24 | 15 | 46 |
| 4 |
|
İstanbulspor AŞ | 26 | 14 | 4 | 8 | 43:29 | 14 | 46 |
| 5 |
|
Eyüpspor | 27 | 12 | 9 | 6 | 40:29 | 11 | 45 |
| 6 |
|
BB Erzurumspor | 27 | 12 | 8 | 7 | 40:31 | 9 | 44 |
| 7 |
|
Samsunspor | 26 | 10 | 9 | 7 | 43:34 | 9 | 39 |
| 8 |
|
Adanaspor | 27 | 10 | 7 | 10 | 31:27 | 4 | 37 |
| 9 |
|
Manisa FK | 27 | 10 | 6 | 11 | 30:33 | -3 | 36 |
| 10 |
|
Boluspor | 26 | 9 | 8 | 9 | 29:28 | 1 | 35 |
| 11 |
|
Keçiörengücü | 26 | 9 | 7 | 10 | 33:35 | -2 | 34 |
| 12 |
|
Tuzlaspor | 26 | 9 | 7 | 10 | 23:25 | -2 | 34 |
| 13 |
|
Gençlerbirliği | 26 | 10 | 3 | 13 | 31:41 | -10 | 33 |
| 14 |
|
Kocaelispor | 26 | 9 | 5 | 12 | 25:32 | -7 | 32 |
| 15 |
|
Menemen Belediyespor | 27 | 7 | 11 | 9 | 33:42 | -9 | 32 |
| 16 |
|
Denizlispor | 27 | 8 | 6 | 13 | 26:39 | -13 | 30 |
| 17 |
|
Altınordu FK | 27 | 9 | 1 | 17 | 30:51 | -21 | 28 |
| 18 |
|
Bursaspor | 26 | 6 | 7 | 13 | 27:39 | -12 | 25 |
| 19 |
|
Balıkesirspor | 26 | 3 | 2 | 21 | 19:47 | -28 | 11 |
| Promotion | |
| Playoffs | |
| Relegation |
