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| 1st(1st leg) | Bayburt İl Özel İdare | - | 1461 Trabzon FK | 0:0 (0:0) | ||
| 2nd (2nd leg) | 1461 Trabzon FK | - | Bayburt İl Özel İdare | 0:2 (0:0) | ||
| 1st(1st leg): 12/05/2022 14:00 | 2nd (2nd leg): 16/05/2022 13:30 | Winner: Bayburt İl Özel İdare | ||||
| 1st(1st leg) | Sivas Belediyespor | - | Bodrumspor | 0:0 (0:0) | ||
| 2nd (2nd leg) | Bodrumspor | - | Sivas Belediyespor | 1:0 (0:0) | ||
| 1st(1st leg): 12/05/2022 14:00 | 2nd (2nd leg): 16/05/2022 14:00 | Winner: Bodrumspor | ||||
| 1st(1st leg) | Tarsus Idman Yurdu | - | Amed SK | 0:0 (0:0) | ||
| 2nd (2nd leg) | Amed SK | - | Tarsus Idman Yurdu | 6:7 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 12/05/2022 18:00 | 2nd (2nd leg): 16/05/2022 18:00 | Winner: Tarsus Idman Yurdu | ||||
| 1st(1st leg) | Isparta 32 SK | - | Karacabey Belediyespor | 0:2 (0:1) | ||
| 2nd (2nd leg) | Karacabey Belediyespor | - | Isparta 32 SK | 2:1 (0:1) | ||
| 1st(1st leg): 12/05/2022 18:00 | 2nd (2nd leg): 16/05/2022 18:00 | Winner: Karacabey Belediyespor | ||||
