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| 1st(1st leg) | Aston Villa | - | FC Barcelona | 2:2 (0:1) | ||
| 2nd (2nd leg) | FC Barcelona | - | Aston Villa | 2:1 (0:0) | ||
| 1st(1st leg): 01/03/1978 | 2nd (2nd leg): 15/03/1978 | Winner: FC Barcelona | ||||
| 1st(1st leg) | SC Bastia | - | FC Carl Zeiss Jena | 7:2 (2:0) | ||
| 2nd (2nd leg) | FC Carl Zeiss Jena | - | SC Bastia | 4:2 (2:1) | ||
| 1st(1st leg): 01/03/1978 | 2nd (2nd leg): 15/03/1978 | Winner: SC Bastia | ||||
| 1st(1st leg) | 1. FC Magdeburg | - | PSV Eindhoven | 1:0 (0:0) | ||
| 2nd (2nd leg) | PSV Eindhoven | - | 1. FC Magdeburg | 4:2 (2:1) | ||
| 1st(1st leg): 01/03/1978 | 2nd (2nd leg): 15/03/1978 | Winner: PSV Eindhoven | ||||
| 1st(1st leg) | Eintracht Frankfurt | - | Grasshopper Club Zürich | 3:2 (0:1) | ||
| 2nd (2nd leg) | Grasshopper Club Zürich | - | Eintracht Frankfurt | 1:0 (1:0) | ||
| 1st(1st leg): 01/03/1978 | 2nd (2nd leg): 14/03/1978 | Winner: Grasshopper Club Zürich | ||||
