1st(1st leg) Sturm Graz - IFK Göteborg 2:2 (2:1)
2nd (2nd leg) IFK Göteborg - Sturm Graz 3:2 (0:0)
1st(1st leg): 20/10/1981 2nd (2nd leg): 04/11/1981 Winner: IFK Göteborg
1st(1st leg) KFC Winterslag - Arsenal FC 1:0 (0:0)
2nd (2nd leg) Arsenal FC - KFC Winterslag 2:1 (1:1)
1st(1st leg): 20/10/1981 2nd (2nd leg): 03/11/1981 Winner: KFC Winterslag
1st(1st leg) Bor. Mönchengladbach - Dundee United 2:0 (0:0)
2nd (2nd leg) Dundee United - Bor. Mönchengladbach 5:0 (2:0)
1st(1st leg): 20/10/1981 2nd (2nd leg): 03/11/1981 Winner: Dundee United
1st(1st leg) Inter - Dinamo Bucureşti 1:1 (1:1)
2nd (2nd leg) Dinamo Bucureşti - Inter 3:2 (1:0, 1:1) aet
1st(1st leg): 21/10/1981 2nd (2nd leg): 04/11/1981 Winner: Dinamo Bucureşti
1st(1st leg) KSK Beveren - Hajduk Split 2:3 (0:2)
2nd (2nd leg) Hajduk Split - KSK Beveren 1:2 (0:2)
1st(1st leg): 21/10/1981 2nd (2nd leg): 04/11/1981 Winner: Hajduk Split
1st(1st leg) Valencia CF - Boavista 2:0 (0:0)
2nd (2nd leg) Boavista - Valencia CF 1:0 (1:0)
1st(1st leg): 21/10/1981 2nd (2nd leg): 04/11/1981 Winner: Valencia CF
1st(1st leg) Real Madrid - FC Carl Zeiss Jena 3:2 (0:1)
2nd (2nd leg) FC Carl Zeiss Jena - Real Madrid 0:0 (0:0)
1st(1st leg): 21/10/1981 2nd (2nd leg): 04/11/1981 Winner: Real Madrid
1st(1st leg) Rapid Wien - PSV Eindhoven 1:0 (0:0)
2nd (2nd leg) PSV Eindhoven - Rapid Wien 2:1 (1:1)
1st(1st leg): 21/10/1981 2nd (2nd leg): 04/11/1981 Winner: Rapid Wien
1st(1st leg) Aris Saloniki - Sporting Lokeren 1:1 (0:0)
2nd (2nd leg) Sporting Lokeren - Aris Saloniki 4:0 (2:0)
1st(1st leg): 21/10/1981 2nd (2nd leg): 04/11/1981 Winner: Sporting Lokeren
1st(1st leg) Spartak Moskva - 1. FC Kaiserslautern 2:1 (1:0)
2nd (2nd leg) 1. FC Kaiserslautern - Spartak Moskva 4:0 (2:0)
1st(1st leg): 21/10/1981 2nd (2nd leg): 04/11/1981 Winner: 1. FC Kaiserslautern
1st(1st leg) Grasshopper Club Zürich - Radnički Niš 2:0 (1:0)
2nd (2nd leg) Radnički Niš - Grasshopper Club Zürich 3:0 (1:0, 2:0, 2:0) pso
1st(1st leg): 21/10/1981 2nd (2nd leg): 04/11/1981 Winner: Radnički Niš
1st(1st leg) Feyenoord - Dynamo Dresden 2:1 (0:1)
2nd (2nd leg) Dynamo Dresden - Feyenoord 1:1 (0:0)
1st(1st leg): 21/10/1981 2nd (2nd leg): 04/11/1981 Winner: Feyenoord
1st(1st leg) Malmö FF - Neuchâtel Xamax FC 0:1 (0:1)
2nd (2nd leg) Neuchâtel Xamax FC - Malmö FF 1:0 (0:0)
1st(1st leg): 21/10/1981 2nd (2nd leg): 03/11/1981 Winner: Neuchâtel Xamax FC
1st(1st leg) Southampton FC - Sporting CP 2:4 (0:3)
2nd (2nd leg) Sporting CP - Southampton FC 0:0 (0:0)
1st(1st leg): 21/10/1981 2nd (2nd leg): 04/11/1981 Winner: Sporting CP
1st(1st leg) Aberdeen FC - Argeș Pitești 3:0 (3:0)
2nd (2nd leg) Argeș Pitești - Aberdeen FC 2:2 (2:0)
1st(1st leg): 21/10/1981 2nd (2nd leg): 04/11/1981 Winner: Aberdeen FC
1st(1st leg) Girondins Bordeaux - Hamburger SV 2:1 (1:1)
2nd (2nd leg) Hamburger SV - Girondins Bordeaux 2:0 (2:0)
1st(1st leg): 21/10/1981 2nd (2nd leg): 04/11/1981 Winner: Hamburger SV