1st(1st leg) AS Roma - FC Zürich 1:0 (0:0)
2nd (2nd leg) FC Zürich - AS Roma 2:2 (0:1)
1st(1st leg): 24/11/1998 15:00 2nd (2nd leg): 08/12/1998 19:45 Winner: AS Roma
1st(1st leg) Bologna FC - Real Betis 4:1 (1:0)
2nd (2nd leg) Real Betis - Bologna FC 1:0 (1:0)
1st(1st leg): 24/11/1998 17:30 2nd (2nd leg): 08/12/1998 18:00 Winner: Bologna FC
1st(1st leg) Grasshopper Club Zürich - Girondins Bordeaux 3:3 (2:2)
2nd (2nd leg) Girondins Bordeaux - Grasshopper Club Zürich 0:0 (0:0)
1st(1st leg): 24/11/1998 17:30 2nd (2nd leg): 08/12/1998 18:30 Winner: Girondins Bordeaux
1st(1st leg) Real Sociedad - Atlético Madrid 2:1 (1:1)
2nd (2nd leg) Atlético Madrid - Real Sociedad 4:1 (2:0, 2:1) aet
1st(1st leg): 24/11/1998 18:45 2nd (2nd leg): 08/12/1998 20:30 Winner: Atlético Madrid
1st(1st leg) Olympique Lyon - Club Brugge KV 1:0 (1:0)
2nd (2nd leg) Club Brugge KV - Olympique Lyon 3:4 (0:1)
1st(1st leg): 24/11/1998 19:00 2nd (2nd leg): 08/12/1998 18:00 Winner: Olympique Lyon
1st(1st leg) AS Monaco - Olympique Marseille 2:2 (1:2)
2nd (2nd leg) Olympique Marseille - AS Monaco 1:0 (0:0)
1st(1st leg): 24/11/1998 19:30 2nd (2nd leg): 08/12/1998 20:00 Winner: Olympique Marseille
1st(1st leg) Rangers FC - Parma AC 1:1 (0:0)
2nd (2nd leg) Parma AC - Rangers FC 3:1 (0:1)
1st(1st leg): 24/11/1998 19:45 2nd (2nd leg): 08/12/1998 13:30 Winner: Parma AC
1st(1st leg) RC Celta - Liverpool FC 3:1 (0:1)
2nd (2nd leg) Liverpool FC - RC Celta 0:1 (0:0)
1st(1st leg): 24/11/1998 20:35 2nd (2nd leg): 08/12/1998 19:45 Winner: RC Celta