1st(1st leg) Iraklis Saloniki - 1. FC Kaiserslautern 1:3 (0:2)
2nd (2nd leg) 1. FC Kaiserslautern - Iraklis Saloniki 2:3 (2:0)
1st(1st leg): 23/10/2000 2nd (2nd leg): 09/11/2000 Winner: 1. FC Kaiserslautern
1st(1st leg) Udinese Calcio - PAOK Saloniki 1:0 (0:0)
2nd (2nd leg) PAOK Saloniki - Udinese Calcio 3:0 (0:0, 1:0) aet
1st(1st leg): 24/10/2000 2nd (2nd leg): 09/11/2000 Winner: PAOK Saloniki
1st(1st leg) Werder Bremen - KRC Genk 4:1 (2:1)
2nd (2nd leg) KRC Genk - Werder Bremen 2:5 (1:3)
1st(1st leg): 24/10/2000 2nd (2nd leg): 09/11/2000 Winner: Werder Bremen
1st(1st leg) NK Osijek - Rapid Wien 2:1 (1:1)
2nd (2nd leg) Rapid Wien - NK Osijek 0:2 (0:1)
1st(1st leg): 24/10/2000 17:00 2nd (2nd leg): 07/11/2000 17:00 Winner: NK Osijek
1st(1st leg) Wisła Kraków - FC Porto 0:0 (0:0)
2nd (2nd leg) FC Porto - Wisła Kraków 3:0 (1:0)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: FC Porto
1st(1st leg) FC Tirol Innsbruck - VfB Stuttgart 1:0 (0:0)
2nd (2nd leg) VfB Stuttgart - FC Tirol Innsbruck 3:1 (3:0)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: VfB Stuttgart
1st(1st leg) Lokomotiv Moskva - Inter Slovnaft Bratislava 1:0 (1:0)
2nd (2nd leg) Inter Slovnaft Bratislava - Lokomotiv Moskva 1:2 (0:1)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: Lokomotiv Moskva
1st(1st leg) Lillestrøm SK - CD Alavés 1:3 (0:2)
2nd (2nd leg) CD Alavés - Lillestrøm SK 2:2 (1:1)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: CD Alavés
1st(1st leg) Hertha BSC - Amica Wronki 3:1 (1:0)
2nd (2nd leg) Amica Wronki - Hertha BSC 1:1 (0:0)
1st(1st leg): 26/10/2000 2nd (2nd leg): 07/11/2000 Winner: Hertha BSC
1st(1st leg) FC Nantes - MTK Hungaria 2:1 (0:1)
2nd (2nd leg) MTK Hungaria - FC Nantes 0:1 (0:0)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: FC Nantes
1st(1st leg) Lausanne Sports - AFC Ajax 1:0 (1:0)
2nd (2nd leg) AFC Ajax - Lausanne Sports 2:2 (1:1)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: Lausanne Sports
1st(1st leg) Parma AC - Dinamo Zagreb 2:0 (0:0)
2nd (2nd leg) Dinamo Zagreb - Parma AC 1:0 (1:0)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: Parma AC
1st(1st leg) AEK Athen - Herfølge BK 5:0 (0:0)
2nd (2nd leg) Herfølge BK - AEK Athen 2:1 (1:1)
1st(1st leg): 26/10/2000 2nd (2nd leg): 07/11/2000 Winner: AEK Athen
1st(1st leg) OFI Heraklion - Slavia Praha 2:2 (1:1)
2nd (2nd leg) Slavia Praha - OFI Heraklion 4:1 (0:0)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: Slavia Praha
1st(1st leg) Club Brugge KV - FC St. Gallen 2:1 (0:1)
2nd (2nd leg) FC St. Gallen - Club Brugge KV 1:1 (1:0)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: Club Brugge KV
1st(1st leg) Halmstads BK - TSV 1860 München 3:2 (2:2)
2nd (2nd leg) TSV 1860 München - Halmstads BK 3:1 (2:1)
1st(1st leg): 26/10/2000 2nd (2nd leg): 07/11/2000 Winner: TSV 1860 München
1st(1st leg) Crvena Zvezda - Celta Vigo 1:0 (0:0)
2nd (2nd leg) Celta Vigo - Crvena Zvezda 3:0 (1:3)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: Celta Vigo
1st(1st leg) Girondins Bordeaux - Celtic FC 1:1 (1:1)
2nd (2nd leg) Celtic FC - Girondins Bordeaux 1:2 (0:0, 1:1) aet
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: Girondins Bordeaux
1st(1st leg) Inter - Vitesse 0:0 (0:0)
2nd (2nd leg) Vitesse - Inter 1:1 (1:0)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: Inter
1st(1st leg) Rayo Vallecano - Viborg FF 1:0 (1:0)
2nd (2nd leg) Viborg FF - Rayo Vallecano 2:1 (1:0)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: Rayo Vallecano
1st(1st leg) Liverpool FC - Slovan Liberec 1:0 (0:0)
2nd (2nd leg) Slovan Liberec - Liverpool FC 2:3 (1:1)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: Liverpool FC
1st(1st leg) FC Basel - Feyenoord 1:2 (0:0)
2nd (2nd leg) Feyenoord - FC Basel 1:0 (1:0)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: Feyenoord
1st(1st leg) Espanyol Barcelona - Grazer AK 4:0 (4:0)
2nd (2nd leg) Grazer AK - Espanyol Barcelona 1:0 (0:0)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: Espanyol Barcelona
1st(1st leg) Boavista - AS Roma 0:1 (0:0)
2nd (2nd leg) AS Roma - Boavista 1:1 (1:0)
1st(1st leg): 26/10/2000 2nd (2nd leg): 09/11/2000 Winner: AS Roma