1st(1st leg) Hertha BSC - Inter 0:0 (0:0)
2nd (2nd leg) Inter - Hertha BSC 2:1 (1:0)
1st(1st leg): 21/11/2000 2nd (2nd leg): 07/12/2000 Winner: Inter
1st(1st leg) Lokomotiv Moskva - Rayo Vallecano 0:0 (0:0)
2nd (2nd leg) Rayo Vallecano - Lokomotiv Moskva 2:0 (0:0)
1st(1st leg): 23/11/2000 2nd (2nd leg): 07/12/2000 Winner: Rayo Vallecano
1st(1st leg) Parma AC - TSV 1860 München 2:2 (2:0)
2nd (2nd leg) TSV 1860 München - Parma AC 0:2 (0:0)
1st(1st leg): 23/11/2000 2nd (2nd leg): 05/12/2000 Winner: Parma AC
1st(1st leg) NK Osijek - Slavia Praha 2:0 (1:0)
2nd (2nd leg) Slavia Praha - NK Osijek 5:1 (2:1)
1st(1st leg): 23/11/2000 2nd (2nd leg): 07/12/2000 Winner: Slavia Praha
1st(1st leg) Shakhtar Donetsk - Celta Vigo 0:0 (0:0)
2nd (2nd leg) Celta Vigo - Shakhtar Donetsk 1:0 (1:0)
1st(1st leg): 23/11/2000 2nd (2nd leg): 07/12/2000 Winner: Celta Vigo
1st(1st leg) FC Nantes - Lausanne Sports 4:3 (2:1)
2nd (2nd leg) Lausanne Sports - FC Nantes 1:3 (0:1)
1st(1st leg): 23/11/2000 2nd (2nd leg): 07/12/2000 Winner: FC Nantes
1st(1st leg) Bayer Leverkusen - AEK Athen 4:4 (2:1)
2nd (2nd leg) AEK Athen - Bayer Leverkusen 2:0 (1:0)
1st(1st leg): 23/11/2000 2nd (2nd leg): 07/12/2000 Winner: AEK Athen
1st(1st leg) PSV Eindhoven - PAOK Saloniki 3:0 (3:0)
2nd (2nd leg) PAOK Saloniki - PSV Eindhoven 0:1 (0:1)
1st(1st leg): 23/11/2000 2nd (2nd leg): 07/12/2000 Winner: PSV Eindhoven
1st(1st leg) Feyenoord - VfB Stuttgart 2:2 (2:1)
2nd (2nd leg) VfB Stuttgart - Feyenoord 2:1 (1:0)
1st(1st leg): 23/11/2000 2nd (2nd leg): 05/12/2000 Winner: VfB Stuttgart
1st(1st leg) Olympiakos Piräus - Liverpool FC 2:2 (0:1)
2nd (2nd leg) Liverpool FC - Olympiakos Piräus 2:0 (1:0)
1st(1st leg): 23/11/2000 2nd (2nd leg): 07/12/2000 Winner: Liverpool FC
1st(1st leg) CD Alavés - Rosenborg BK 1:1 (0:0)
2nd (2nd leg) Rosenborg BK - CD Alavés 1:3 (0:2)
1st(1st leg): 23/11/2000 2nd (2nd leg): 07/12/2000 Winner: CD Alavés
1st(1st leg) Club Brugge KV - FC Barcelona 0:2 (0:2)
2nd (2nd leg) FC Barcelona - Club Brugge KV 1:1 (1:1)
1st(1st leg): 23/11/2000 2nd (2nd leg): 07/12/2000 Winner: FC Barcelona
1st(1st leg) AS Roma - Hamburger SV 1:0 (1:0)
2nd (2nd leg) Hamburger SV - AS Roma 0:3 (0:1)
1st(1st leg): 23/11/2000 2nd (2nd leg): 07/12/2000 Winner: AS Roma
1st(1st leg) Girondins Bordeaux - Werder Bremen 4:1 (2:1)
2nd (2nd leg) Werder Bremen - Girondins Bordeaux 0:0 (0:0)
1st(1st leg): 23/11/2000 2nd (2nd leg): 07/12/2000 Winner: Girondins Bordeaux
1st(1st leg) Espanyol Barcelona - FC Porto 0:2 (0:0)
2nd (2nd leg) FC Porto - Espanyol Barcelona 0:0 (0:0)
1st(1st leg): 23/11/2000 2nd (2nd leg): 07/12/2000 Winner: FC Porto
1st(1st leg) Rangers FC - 1. FC Kaiserslautern 1:0 (0:0)
2nd (2nd leg) 1. FC Kaiserslautern - Rangers FC 3:0 (1:0)
1st(1st leg): 30/11/2000 2nd (2nd leg): 07/12/2000 Winner: 1. FC Kaiserslautern