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| 1st(1st leg) | Partizan | - | Dnipro Dnipropetrovsk | 2:2 (2:1) | ||
| 2nd (2nd leg) | Dnipro Dnipropetrovsk | - | Partizan | 0:1 (0:0) | ||
| 1st(1st leg): 16/02/2005 16:00 | 2nd (2nd leg): 24/02/2005 16:00 | Winner: Partizan | ||||
| 1st(1st leg) | Shakhtar Donetsk | - | FC Schalke 04 | 1:1 (0:1) | ||
| 2nd (2nd leg) | FC Schalke 04 | - | Shakhtar Donetsk | 0:1 (0:1) | ||
| 1st(1st leg): 16/02/2005 17:15 | 2nd (2nd leg): 24/02/2005 17:00 | Winner: Shakhtar Donetsk | ||||
| 1st(1st leg) | Panathinaikos | - | Sevilla FC | 1:0 (0:0) | ||
| 2nd (2nd leg) | Sevilla FC | - | Panathinaikos | 2:0 (0:0) | ||
| 1st(1st leg): 16/02/2005 18:00 | 2nd (2nd leg): 24/02/2005 20:30 | Winner: Sevilla FC | ||||
| 1st(1st leg) | AFC Ajax | - | AJ Auxerre | 1:0 (1:0) | ||
| 2nd (2nd leg) | AJ Auxerre | - | AFC Ajax | 3:1 (1:1) | ||
| 1st(1st leg): 16/02/2005 19:00 | 2nd (2nd leg): 24/02/2005 19:45 | Winner: AJ Auxerre | ||||
| 1st(1st leg) | Parma FC | - | VfB Stuttgart | 0:0 (0:0) | ||
| 2nd (2nd leg) | VfB Stuttgart | - | Parma FC | 0:2 (0:0, 0:0) aet | ||
| 1st(1st leg): 16/02/2005 19:30 | 2nd (2nd leg): 24/02/2005 19:30 | Winner: Parma FC | ||||
| 1st(1st leg) | Valencia CF | - | FC Steaua Bucureşti | 2:0 (1:0) | ||
| 2nd (2nd leg) | FC Steaua Bucureşti | - | Valencia CF | 4:3 (0:0, 2:0, 2:0) pso | ||
| 1st(1st leg): 16/02/2005 20:30 | 2nd (2nd leg): 24/02/2005 18:00 | Winner: FC Steaua Bucureşti | ||||
| 1st(1st leg) | Sporting CP | - | Feyenoord | 2:1 (2:1) | ||
| 2nd (2nd leg) | Feyenoord | - | Sporting CP | 1:2 (0:0) | ||
| 1st(1st leg): 16/02/2005 21:15 | 2nd (2nd leg): 24/02/2005 19:45 | Winner: Sporting CP | ||||
| 1st(1st leg) | Dinamo Kiev | - | Villarreal CF | 0:0 (0:0) | ||
| 2nd (2nd leg) | Villarreal CF | - | Dinamo Kiev | 2:0 (2:0) | ||
| 1st(1st leg): 17/02/2005 16:00 | 2nd (2nd leg): 24/02/2005 20:30 | Winner: Villarreal CF | ||||
| 1st(1st leg) | Grazer AK | - | Middlesbrough FC | 2:2 (0:0) | ||
| 2nd (2nd leg) | Middlesbrough FC | - | Grazer AK | 2:1 (1:1) | ||
| 1st(1st leg): 17/02/2005 17:30 | 2nd (2nd leg): 24/02/2005 20:00 | Winner: Middlesbrough FC | ||||
| 1st(1st leg) | CSKA Moskva | - | SL Benfica | 2:0 (1:0) | ||
| 2nd (2nd leg) | SL Benfica | - | CSKA Moskva | 1:1 (0:0) | ||
| 1st(1st leg): 17/02/2005 18:00 | 2nd (2nd leg): 24/02/2005 20:30 | Winner: CSKA Moskva | ||||
| 1st(1st leg) | Fenerbahçe | - | Real Zaragoza | 0:1 (0:0) | ||
| 2nd (2nd leg) | Real Zaragoza | - | Fenerbahçe | 2:1 (1:0) | ||
| 1st(1st leg): 17/02/2005 18:00 | 2nd (2nd leg): 24/02/2005 19:45 | Winner: Real Zaragoza | ||||
| 1st(1st leg) | FC Basel | - | Lille OSC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Lille OSC | - | FC Basel | 2:0 (1:0) | ||
| 1st(1st leg): 17/02/2005 19:30 | 2nd (2nd leg): 24/02/2005 20:00 | Winner: Lille OSC | ||||
| 1st(1st leg) | Alemannia Aachen | - | AZ Alkmaar | 0:0 (0:0) | ||
| 2nd (2nd leg) | AZ Alkmaar | - | Alemannia Aachen | 2:1 (0:1) | ||
| 1st(1st leg): 17/02/2005 19:30 | 2nd (2nd leg): 24/02/2005 17:30 | Winner: AZ Alkmaar | ||||
| 1st(1st leg) | sc Heerenveen | - | Newcastle United | 1:2 (1:0) | ||
| 2nd (2nd leg) | Newcastle United | - | sc Heerenveen | 2:1 (2:0) | ||
| 1st(1st leg): 17/02/2005 19:45 | 2nd (2nd leg): 24/02/2005 19:45 | Winner: Newcastle United | ||||
| 1st(1st leg) | Olympiakos Piraeus | - | FC Sochaux | 1:0 (1:0) | ||
| 2nd (2nd leg) | FC Sochaux | - | Olympiakos Piraeus | 0:1 (0:0) | ||
| 1st(1st leg): 17/02/2005 19:45 | 2nd (2nd leg): 24/02/2005 18:00 | Winner: Olympiakos Piraeus | ||||
| 1st(1st leg) | Austria Wien | - | Athletic Bilbao | 0:0 (0:0) | ||
| 2nd (2nd leg) | Athletic Bilbao | - | Austria Wien | 1:2 (1:1) | ||
| 1st(1st leg): 24/02/2005 18:30 | 2nd (2nd leg): 27/02/2005 17:00 | Winner: Austria Wien | ||||
