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| 1st(1st leg) | Partizan | - | CSKA Moskva | 1:1 (0:1) | ||
| 2nd (2nd leg) | CSKA Moskva | - | Partizan | 2:0 (0:0) | ||
| 1st(1st leg): 10/03/2005 16:00 | 2nd (2nd leg): 17/03/2005 17:30 | Winner: CSKA Moskva | ||||
| 1st(1st leg) | Olympiakos Piraeus | - | Newcastle United | 1:3 (1:2) | ||
| 2nd (2nd leg) | Newcastle United | - | Olympiakos Piraeus | 4:0 (2:0) | ||
| 1st(1st leg): 10/03/2005 17:00 | 2nd (2nd leg): 16/03/2005 19:45 | Winner: Newcastle United | ||||
| 1st(1st leg) | Shakhtar Donetsk | - | AZ Alkmaar | 1:3 (1:1) | ||
| 2nd (2nd leg) | AZ Alkmaar | - | Shakhtar Donetsk | 2:1 (1:0) | ||
| 1st(1st leg): 10/03/2005 17:00 | 2nd (2nd leg): 16/03/2005 19:30 | Winner: AZ Alkmaar | ||||
| 1st(1st leg) | Austria Wien | - | Real Zaragoza | 1:1 (1:0) | ||
| 2nd (2nd leg) | Real Zaragoza | - | Austria Wien | 2:2 (0:2) | ||
| 1st(1st leg): 10/03/2005 18:30 | 2nd (2nd leg): 17/03/2005 19:45 | Winner: Austria Wien | ||||
| 1st(1st leg) | Lille OSC | - | AJ Auxerre | 0:1 (0:1) | ||
| 2nd (2nd leg) | AJ Auxerre | - | Lille OSC | 0:0 (0:0) | ||
| 1st(1st leg): 10/03/2005 19:30 | 2nd (2nd leg): 17/03/2005 19:45 | Winner: AJ Auxerre | ||||
| 1st(1st leg) | Middlesbrough FC | - | Sporting CP | 2:3 (0:0) | ||
| 2nd (2nd leg) | Sporting CP | - | Middlesbrough FC | 1:0 (0:0) | ||
| 1st(1st leg): 10/03/2005 20:10 | 2nd (2nd leg): 17/03/2005 19:45 | Winner: Sporting CP | ||||
| 1st(1st leg) | Sevilla FC | - | Parma FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Parma FC | - | Sevilla FC | 1:0 (1:0) | ||
| 1st(1st leg): 10/03/2005 20:30 | 2nd (2nd leg): 17/03/2005 19:45 | Winner: Parma FC | ||||
| 1st(1st leg) | FC Steaua Bucureşti | - | Villarreal CF | 0:0 (0:0) | ||
| 2nd (2nd leg) | Villarreal CF | - | FC Steaua Bucureşti | 2:0 (1:0) | ||
| 1st(1st leg): 16/03/2005 18:00 | 2nd (2nd leg): 20/03/2005 19:00 | Winner: Villarreal CF | ||||
