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| 1st(1st leg) | RSC Anderlecht | - | Bayern München | 0:5 (0:2) | ||
| 2nd (2nd leg) | Bayern München | - | RSC Anderlecht | 1:2 (1:2) | ||
| 1st(1st leg): 06/03/2008 18:00 | 2nd (2nd leg): 12/03/2008 19:45 | Winner: Bayern München | ||||
| 1st(1st leg) | ACF Fiorentina | - | Everton FC | 2:0 (0:0) | ||
| 2nd (2nd leg) | Everton FC | - | ACF Fiorentina | 2:4 (1:0, 2:0, 2:0) pso | ||
| 1st(1st leg): 06/03/2008 19:45 | 2nd (2nd leg): 12/03/2008 19:45 | Winner: ACF Fiorentina | ||||
| 1st(1st leg) | Olympique Marseille | - | Zenit St. Petersburg | 3:1 (1:0) | ||
| 2nd (2nd leg) | Zenit St. Petersburg | - | Olympique Marseille | 2:0 (1:0) | ||
| 1st(1st leg): 06/03/2008 19:45 | 2nd (2nd leg): 12/03/2008 16:30 | Winner: Zenit St. Petersburg | ||||
| 1st(1st leg) | Rangers FC | - | Werder Bremen | 2:0 (1:0) | ||
| 2nd (2nd leg) | Werder Bremen | - | Rangers FC | 1:0 (0:0) | ||
| 1st(1st leg): 06/03/2008 20:00 | 2nd (2nd leg): 13/03/2008 19:30 | Winner: Rangers FC | ||||
| 1st(1st leg) | Bolton Wanderers | - | Sporting CP | 1:1 (1:0) | ||
| 2nd (2nd leg) | Sporting CP | - | Bolton Wanderers | 1:0 (0:0) | ||
| 1st(1st leg): 06/03/2008 20:00 | 2nd (2nd leg): 13/03/2008 20:00 | Winner: Sporting CP | ||||
| 1st(1st leg) | Bayer Leverkusen | - | Hamburger SV | 1:0 (0:0) | ||
| 2nd (2nd leg) | Hamburger SV | - | Bayer Leverkusen | 3:2 (0:1) | ||
| 1st(1st leg): 06/03/2008 20:05 | 2nd (2nd leg): 12/03/2008 16:45 | Winner: Bayer Leverkusen | ||||
| 1st(1st leg) | Tottenham Hotspur | - | PSV Eindhoven | 0:1 (0:1) | ||
| 2nd (2nd leg) | PSV Eindhoven | - | Tottenham Hotspur | 6:5 (0:0, 0:1, 0:1) pso | ||
| 1st(1st leg): 06/03/2008 20:05 | 2nd (2nd leg): 12/03/2008 19:45 | Winner: PSV Eindhoven | ||||
| 1st(1st leg) | SL Benfica | - | Getafe CF | 1:2 (0:1) | ||
| 2nd (2nd leg) | Getafe CF | - | SL Benfica | 1:0 (0:0) | ||
| 1st(1st leg): 06/03/2008 20:30 | 2nd (2nd leg): 12/03/2008 20:00 | Winner: Getafe CF | ||||
