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| 1st(1st leg) | Bayer Leverkusen | - | Zenit St. Petersburg | 1:4 (1:1) | ||
| 2nd (2nd leg) | Zenit St. Petersburg | - | Bayer Leverkusen | 0:1 (0:1) | ||
| 1st(1st leg): 03/04/2008 17:30 | 2nd (2nd leg): 10/04/2008 17:30 | Winner: Zenit St. Petersburg | ||||
| 1st(1st leg) | Rangers FC | - | Sporting CP | 0:0 (0:0) | ||
| 2nd (2nd leg) | Sporting CP | - | Rangers FC | 0:2 (0:0) | ||
| 1st(1st leg): 03/04/2008 19:45 | 2nd (2nd leg): 10/04/2008 19:45 | Winner: Rangers FC | ||||
| 1st(1st leg) | Bayern München | - | Getafe CF | 1:1 (1:0) | ||
| 2nd (2nd leg) | Getafe CF | - | Bayern München | 3:3 (1:0, 1:1) aet | ||
| 1st(1st leg): 03/04/2008 19:45 | 2nd (2nd leg): 10/04/2008 19:45 | Winner: Bayern München | ||||
| 1st(1st leg) | ACF Fiorentina | - | PSV Eindhoven | 1:1 (0:0) | ||
| 2nd (2nd leg) | PSV Eindhoven | - | ACF Fiorentina | 0:2 (0:1) | ||
| 1st(1st leg): 03/04/2008 19:45 | 2nd (2nd leg): 10/04/2008 19:45 | Winner: ACF Fiorentina | ||||
