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| 1st(1st leg) | Sud América | - | Juventud de Las Piedras | 2:0 (1:0) | ||
| 2nd (2nd leg) | Juventud de Las Piedras | - | Sud América | 1:0 (1:0) | ||
| 1st(1st leg): 03/12/2020 22:00 | 2nd (2nd leg): 19/01/2021 20:15 | Winner: Sud América | ||||
| 1st(1st leg) | Racing | - | Rampla Juniors | 1:0 (1:0) | ||
| 2nd (2nd leg) | Rampla Juniors | - | Racing | 3:0 (0:0) | ||
| 1st(1st leg): 04/12/2020 00:15 | 2nd (2nd leg): 09/12/2020 22:15 | Winner: Rampla Juniors | ||||
