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| 1st(1st leg) | CA Cerro | - | Defensor Sporting | 1:2 (1:1) | ||
| 2nd (2nd leg) | Defensor Sporting | - | CA Cerro | 0:1 (0:0) | ||
| 1st(1st leg): 30/11/2021 22:00 | 2nd (2nd leg): 04/12/2021 00:45 | Winner: Defensor Sporting | ||||
| 1st(1st leg) | Central Español | - | Racing | 0:0 (0:0) | ||
| 2nd (2nd leg) | Racing | - | Central Español | 1:1 (0:1) | ||
| 1st(1st leg): 01/12/2021 00:45 | 2nd (2nd leg): 03/12/2021 22:00 | Winner: Central Español | ||||
