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| 1st(1st leg) | Chicago Fire | - | D.C. United | 0:0 (0:0) | ||
| 2nd (2nd leg) | D.C. United | - | Chicago Fire | 0:4 (0:3) | ||
| 1st(1st leg): 22/10/2005 02:00 | 2nd (2nd leg): 30/10/2005 21:30 | Winner: Chicago Fire | ||||
| 1st(1st leg) | MetroStars | - | New England Revolution | 1:0 (1:0) | ||
| 2nd (2nd leg) | New England Revolution | - | MetroStars | 3:1 (0:0) | ||
| 1st(1st leg): 23/10/2005 00:00 | 2nd (2nd leg): 30/10/2005 01:00 | Winner: New England Revolution | ||||
| 1st(1st leg) | Colorado Rapids | - | FC Dallas | 0:0 (0:0) | ||
| 2nd (2nd leg) | FC Dallas | - | Colorado Rapids | 4:5 (0:1, 1:1, 2:2) pso | ||
| 1st(1st leg): 23/10/2005 02:00 | 2nd (2nd leg): 30/10/2005 01:30 | Winner: Colorado Rapids | ||||
| 1st(1st leg) | Los Angeles Galaxy | - | San Jose Earthquakes | 3:1 (2:0) | ||
| 2nd (2nd leg) | San Jose Earthquakes | - | Los Angeles Galaxy | 1:1 (1:0) | ||
| 1st(1st leg): 23/10/2005 20:00 | 2nd (2nd leg): 30/10/2005 03:00 | Winner: Los Angeles Galaxy | ||||
