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| 1st(1st leg) | Colorado Rapids | - | Columbus Crew | 1:0 (1:0) | ||
| 2nd (2nd leg) | Columbus Crew | - | Colorado Rapids | 4:5 (1:0, 2:1, 2:1) pso | ||
| 1st(1st leg): 29/10/2010 02:00 | 2nd (2nd leg): 06/11/2010 20:00 | Winner: Colorado Rapids | ||||
| 1st(1st leg) | FC Dallas | - | Real Salt Lake | 2:1 (1:1) | ||
| 2nd (2nd leg) | Real Salt Lake | - | FC Dallas | 1:1 (0:1) | ||
| 1st(1st leg): 30/10/2010 22:00 | 2nd (2nd leg): 07/11/2010 02:00 | Winner: FC Dallas | ||||
| 1st(1st leg) | San Jose Earthquakes | - | New York RB | 0:1 (0:0) | ||
| 2nd (2nd leg) | New York RB | - | San Jose Earthquakes | 1:3 (0:1) | ||
| 1st(1st leg): 31/10/2010 02:00 | 2nd (2nd leg): 05/11/2010 00:00 | Winner: San Jose Earthquakes | ||||
| 1st(1st leg) | Seattle Sounders | - | Los Angeles Galaxy | 0:1 (0:1) | ||
| 2nd (2nd leg) | Los Angeles Galaxy | - | Seattle Sounders | 2:1 (2:0) | ||
| 1st(1st leg): 01/11/2010 00:00 | 2nd (2nd leg): 08/11/2010 02:00 | Winner: Los Angeles Galaxy | ||||
