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| 1st(1st leg) | Columbus Crew | - | New York RB | 1:0 (0:0) | ||
| 2nd (2nd leg) | New York RB | - | Columbus Crew | 3:0 (1:0) | ||
| 1st(1st leg): 04/11/2018 20:00 | 2nd (2nd leg): 12/11/2018 00:30 | Winner: New York RB | ||||
| 1st(1st leg) | Portland Timbers | - | Seattle Sounders | 2:1 (2:1) | ||
| 2nd (2nd leg) | Seattle Sounders | - | Portland Timbers | 2:4 (0:0, 2:1, 3:2) pso | ||
| 1st(1st leg): 04/11/2018 22:30 | 2nd (2nd leg): 09/11/2018 03:30 | Winner: Portland Timbers | ||||
| 1st(1st leg) | New York City FC | - | Atlanta United FC | 0:1 (0:1) | ||
| 2nd (2nd leg) | Atlanta United FC | - | New York City FC | 3:1 (2:1) | ||
| 1st(1st leg): 05/11/2018 00:30 | 2nd (2nd leg): 11/11/2018 22:30 | Winner: Atlanta United FC | ||||
| 1st(1st leg) | Real Salt Lake | - | Sporting Kansas City | 1:1 (0:0) | ||
| 2nd (2nd leg) | Sporting Kansas City | - | Real Salt Lake | 4:2 (2:0) | ||
| 1st(1st leg): 05/11/2018 03:00 | 2nd (2nd leg): 11/11/2018 20:00 | Winner: Sporting Kansas City | ||||
