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 |
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| 24/09/2022 | 20:00 | Columbus Crew 2 | - | Rochester NYFC | 4:1 | |
| 25/09/2022 | 00:00 | Toronto FC 2 | - | Philadelphia Union 2 | 1:0 | |
| 26/09/2022 | 00:30 | St. Louis City SC 2 | - | North Texas SC | 2:0 | |
| 03:30 | Tacoma Defiance | - | Houston Dynamo 2 | 5:4 pso |
|
|
|
| 24/09/2022 | 20:00 | Columbus Crew 2 | - | Rochester NYFC | 4:1 | |
| 25/09/2022 | 00:00 | Toronto FC 2 | - | Philadelphia Union 2 | 1:0 | |
| 26/09/2022 | 00:30 | St. Louis City SC 2 | - | North Texas SC | 2:0 | |
| 03:30 | Tacoma Defiance | - | Houston Dynamo 2 | 5:4 pso |
