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| 16/07/2021 | 19:45 | Briton Ferry Llansawel AFC | - | Pontypridd Town | 3:4 (1:1, 2:2) pso | |
| 19:45 | Llanelli Town | - | Newport County | 5:0 (3:0) | ||
| 19:45 | Bangor City | - | Holyhead Hotspur | 4:0 (1:0) | ||
| 19:45 | Llandudno FC | - | Denbigh Town | 3:0 (1:1, 3:3) pso | ||
| 17/07/2021 | Port Talbot Town | - | Swansea University | dnp | ||
| 14:30 | Trefelin BGC | - | Taff's Well AFC | 2:0 (0:0) | ||
| 14:30 | Cambrian & Clydach | - | Carmarthen Town | 4:1 (3:0) | ||
| 14:30 | Llantwit Major FC | - | Risca United | 2:4 (3:1, 3:3) pso | ||
| 14:30 | Cwmbran Celtic | - | Afan Lido FC | 3:0 (3:0) | ||
| 14:30 | Llangefni Town FC | - | Prestatyn Town | 1:2 (0:0) | ||
| 14:30 | Holywell Town | - | Colwyn Bay FC | 2:1 (0:1) | ||
| 14:30 | Airbus UK | - | Guilsfield FC | 6:5 (1:0, 1:1) pso | ||
| 14:30 | Llanidloes Town FC | - | Gresford Athletic | 2:3 (1:1) | ||
| 14:30 | Llanrhaeadr-ym-Mochnant | - | Penrhyncoch FC | 1:4 (1:2) |
