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| 22/07/2022 | 19:30 | Denbigh Town | - | Gresford Athletic | 0:1 (0:0) | |
| 19:30 | Taff's Well AFC | - | Ynyshir Albions FC | 4:1 (3:1) | ||
| 19:30 | Swansea University | - | Cambrian & Clydach | 5:4 (2:2, 3:3) pso | ||
| 19:45 | Ruthin Town | - | Porthmadog FC | 4:1 (0:1) | ||
| 19:45 | Llanelli Town | - | Abergavenny Town | 0:2 (1:1, 1:1) pso | ||
| 23/07/2022 | 14:30 | Holyhead Hotspur | - | Llandudno FC | 1:2 (0:2) | |
| 14:30 | Caersws FC | - | Prestatyn Town | 5:3 (1:1, 1:1) pso | ||
| 14:30 | Penrhyncoch FC | - | Buckley Town | 0:2 (0:1) | ||
| 14:30 | Mold Alexandra | - | Holywell Town | 2:3 (0:1) | ||
| 14:30 | Llantwit Major FC | - | Carmarthen Town | 0:2 (0:0) | ||
| 14:30 | Goytre United | - | Trefelin BGC | 1:6 (0:3) | ||
| 14:30 | Pontardawe Town | - | Llanidloes Town FC | 1:2 (0:0) | ||
| 24/07/2022 | 14:30 | Chirk AAA | - | Conwy Borough FC | 1:0 (0:0) | |
| 25/07/2022 | 19:30 | Briton Ferry Llansawel AFC | - | Afan Lido FC | 3:2 (1:0) |
