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| 1st(1st leg) | St. Kitts & Nevis | - | El Salvador | 0:4 (0:3) | ||
| 2nd (2nd leg) | El Salvador | - | St. Kitts & Nevis | 2:0 (1:0) | ||
| 1st(1st leg): 12/06/2021 21:00 | 2nd (2nd leg): 16/06/2021 02:05 | Winner: El Salvador | ||||
| 1st(1st leg) | Haiti | - | Canada | 0:1 (0:1) | ||
| 2nd (2nd leg) | Canada | - | Haiti | 3:0 (0:0) | ||
| 1st(1st leg): 12/06/2021 22:00 | 2nd (2nd leg): 16/06/2021 02:05 | Winner: Canada | ||||
| 1st(1st leg) | Panama | - | Curaçao | 2:1 (0:0) | ||
| 2nd (2nd leg) | Curaçao | - | Panama | 0:0 (0:0) | ||
| 1st(1st leg): 13/06/2021 00:05 | 2nd (2nd leg): 16/06/2021 01:00 | Winner: Panama | ||||
