| Champions League | M. | W | D | L | goals | |||
| at home | 1 | 0 | 0 | 1 | 1 | : | 6 | |
| Away | 1 | 0 | 0 | 1 | 2 | : | 4 | |
| ∑ | 2 | 0 | 0 | 2 | 3 | : | 10 | |
| Europa League | M. | W | D | L | goals | |||
| at home | 1 | 1 | 0 | 0 | 4 | : | 0 | |
| Away | 1 | 0 | 0 | 1 | 0 | : | 1 | |
| ∑ | 2 | 1 | 0 | 1 | 4 | : | 1 | |
| overall | M. | W | D | L | goals | |||
| at home | 2 | 1 | 0 | 1 | 5 | : | 6 | |
| Away | 2 | 0 | 0 | 2 | 2 | : | 5 | |
| Neutral Place | 0 | 0 | 0 | 0 | 0 | : | 0 | |
| ∑ | 4 | 1 | 0 | 3 | 7 | : | 11 | |
| Champions League | |||||
| 2022/2023 | Group A | SSC Napoli | - | AFC Ajax | 4:2 (2:0) |
| 2022/2023 | Group A | AFC Ajax | - | SSC Napoli | 1:6 (1:3) |
| Europa League | |||||
| 1969/1970 | Round of 16 | AFC Ajax | - | SSC Napoli | 4:0 (1:0, 1:0) aet |
| 1969/1970 | Round of 16 | SSC Napoli | - | AFC Ajax | 1:0 (1:0) |
|
For games that were decided on penalties the score after 120 minutes will be included in the ranking |
Netherlands 
![AFC Ajax [Women]](https://s.hs-data.com/bilder/wappen/mini/18743.gif?fallback=png "AFC Ajax [Women]"){kind=small}
![AFC Ajax [U18]](https://s.hs-data.com/bilder/wappen/mini/34848.gif?fallback=png "AFC Ajax [U18]"){kind=small}
![AFC Ajax [Youth]](https://s.hs-data.com/bilder/wappen/mini/14190.gif?fallback=png "AFC Ajax [Youth]"){kind=small}
![AFC Ajax [Youth B]](https://s.hs-data.com/bilder/wappen/mini/15198.gif?fallback=png "AFC Ajax [Youth B]"){kind=small}
![AFC Ajax [Youth B Women]](https://s.hs-data.com/bilder/wappen/mini/32887.gif?fallback=png "AFC Ajax [Youth B Women]"){kind=small}
![AFC Ajax [Youth C]](https://s.hs-data.com/bilder/wappen/mini/24209.gif?fallback=png "AFC Ajax [Youth C]"){kind=small}
