Championship   M. W D L goals
  at home 19 9 4 6 28 : 20
  Away 19 3 5 11 18 : 42
  38 12 9 17 46 : 62
FA Cup   M. W D L goals
  Away 1 0 0 1 0 : 1
  1 0 0 1 0 : 1
League Cup   M. W D L goals
  at home 1 1 0 0 1 : 0
  Away 1 0 0 1 1 : 4
  2 1 0 1 2 : 4
League Two   M. W D L goals
  at home 6 1 2 3 6 : 9
  Away 6 4 1 1 10 : 5
  12 5 3 4 16 : 14
overall   M. W D L goals
  at home 26 11 6 9 35 : 29
  Away 27 7 6 14 29 : 52
  Neutral Place 0 0 0 0 0 : 0
  53 18 12 23 64 : 81
Championship
1981/1982 6. Round Grimsby Town - Leyton Orient 1:2
1981/1982 2. Round Leyton Orient - Grimsby Town 1:2
1980/1981 7. Round Grimsby Town - Leyton Orient 2:0
1980/1981 2. Round Leyton Orient - Grimsby Town 2:0
1963/1964 5. Round Leyton Orient - Grimsby Town 0:0
1963/1964 5. Round Grimsby Town - Leyton Orient 1:1
1958/1959 9. Round Grimsby Town - Leyton Orient 4:1
1958/1959 5. Round Leyton Orient - Grimsby Town 0:1
1957/1958 5. Round Leyton Orient - Grimsby Town 5:1
1957/1958 1. Round Grimsby Town - Leyton Orient 7:2
1956/1957 6. Round Leyton Orient - Grimsby Town 1:1
1956/1957 2. Round Grimsby Town - Leyton Orient 0:0
1928/1929 8. Round Clapton Orient - Grimsby Town 3:1
1928/1929 2. Round Grimsby Town - Clapton Orient 6:1
1927/1928 5. Round Clapton Orient - Grimsby Town 1:2
1927/1928 1. Round Grimsby Town - Clapton Orient 2:2
1926/1927 9. Round Grimsby Town - Clapton Orient 2:2
1926/1927 5. Round Clapton Orient - Grimsby Town 2:4
1919/1920 8. Round Grimsby Town - Clapton Orient 2:0
1919/1920 8. Round Clapton Orient - Grimsby Town 3:0
1914/1915 7. Round Clapton Orient - Grimsby Town 2:1
1914/1915 3. Round Grimsby Town - Clapton Orient 2:1
1913/1914 8. Round Clapton Orient - Grimsby Town 0:0
1913/1914 4. Round Grimsby Town - Clapton Orient 2:0
1912/1913 7. Round Clapton Orient - Grimsby Town 1:3
1912/1913 3. Round Grimsby Town - Clapton Orient 1:2
1911/1912 6. Round Grimsby Town - Clapton Orient 2:1
1911/1912 2. Round Clapton Orient - Grimsby Town 1:0
1909/1910 5. Round Clapton Orient - Grimsby Town 0:0
1909/1910 1. Round Grimsby Town - Clapton Orient 2:0
1908/1909 7. Round Clapton Orient - Grimsby Town 2:1
1908/1909 3. Round Grimsby Town - Clapton Orient 1:0
1907/1908 7. Round Grimsby Town - Clapton Orient 0:0
1907/1908 3. Round Clapton Orient - Grimsby Town 2:1
1906/1907 7. Round Grimsby Town - Clapton Orient 1:2
1906/1907 3. Round Clapton Orient - Grimsby Town 1:0
1905/1906 6. Round Grimsby Town - Clapton Orient 4:1
1905/1906 2. Round Clapton Orient - Grimsby Town 1:2
FA Cup
1933/1934 3. Round Grimsby Town - Clapton Orient 1:0
League Cup
1999/2000 2. Round Leyton Orient - Grimsby Town 1:0 (1:0)
1999/2000 2. Round Grimsby Town - Leyton Orient 4:1 (2:1)
League Two
2022/2023 34. Round Grimsby Town - Leyton Orient 2:2 (0:1)
2022/2023 1. Round Leyton Orient - Grimsby Town 2:0 (0:0)
2020/2021 33. Round Grimsby Town - Leyton Orient 0:1 (0:1)
2020/2021 6. Round Leyton Orient - Grimsby Town 2:3 (1:2)
2019/2020 27. Round Leyton Orient - Grimsby Town 1:1 (0:0)
2019/2020 14. Round Grimsby Town - Leyton Orient 0:4 (0:2)
2016/2017 36. Round Leyton Orient - Grimsby Town 0:3 (0:1)
2016/2017 4. Round Grimsby Town - Leyton Orient 1:2 (0:0)
2005/2006 43. Round Leyton Orient - Grimsby Town 0:0 (0:0)
2005/2006 15. Round Grimsby Town - Leyton Orient 0:1 (0:1)
2004/2005 28. Round Leyton Orient - Grimsby Town 1:2
2004/2005 9. Round Grimsby Town - Leyton Orient 2:0

For games that were decided on penalties the score after 120 minutes will be included in the ranking