Friendlies Clubs   M. W D L goals
  at home 1 0 0 1 1 : 3
  1 0 0 1 1 : 3
Championship   M. W D L goals
  at home 21 10 7 4 39 : 25
  Away 20 4 7 9 22 : 35
  41 14 14 13 61 : 60
FA Cup   M. W D L goals
  at home 1 0 0 1 0 : 1
  1 0 0 1 0 : 1
League Cup   M. W D L goals
  Away 1 0 0 1 1 : 2
  1 0 0 1 1 : 2
overall   M. W D L goals
  at home 23 10 7 6 40 : 29
  Away 21 4 7 10 23 : 37
  Neutral Place 0 0 0 0 0 : 0
  44 14 14 16 63 : 66
Friendlies Clubs
2019 Week Preston North End - Southampton FC 1:3 (1:2)
Championship
2023/2024 13. Round Preston North End - Southampton FC 2:2 (0:1)
2008/2009 34. Round Southampton FC - Preston North End 3:1 (3:0)
2008/2009 15. Round Preston North End - Southampton FC 2:3 (2:0)
2007/2008 23. Round Southampton FC - Preston North End 0:1 (0:0)
2007/2008 9. Round Preston North End - Southampton FC 5:1 (1:1)
2006/2007 36. Round Preston North End - Southampton FC 3:1 (1:0)
2006/2007 5. Round Southampton FC - Preston North End 1:1 (1:0)
2005/2006 34. Round Southampton FC - Preston North End 0:0 (0:0)
2005/2006 12. Round Preston North End - Southampton FC 1:1 (0:1)
1965/1966 9. Round Preston North End - Southampton FC 1:1
1965/1966 4. Round Southampton FC - Preston North End 5:2
1964/1965 4. Round Preston North End - Southampton FC 0:0
1964/1965 2. Round Southampton FC - Preston North End 3:1
1963/1964 6. Round Preston North End - Southampton FC 2:1
1963/1964 2. Round Southampton FC - Preston North End 4:5
1962/1963 6. Round Preston North End - Southampton FC 1:0
1962/1963 3. Round Southampton FC - Preston North End 1:0
1961/1962 9. Round Preston North End - Southampton FC 1:1
1961/1962 3. Round Southampton FC - Preston North End 0:0
1950/1951 8. Round Southampton FC - Preston North End 3:3
1950/1951 4. Round Preston North End - Southampton FC 3:2
1949/1950 5. Round Preston North End - Southampton FC 0:3
1949/1950 2. Round Southampton FC - Preston North End 1:0
1933/1934 10. Round Southampton FC - Preston North End 0:1
1933/1934 5. Round Preston North End - Southampton FC 3:1
1932/1933 10. Round Preston North End - Southampton FC 3:1
1932/1933 5. Round Southampton FC - Preston North End 1:0
1931/1932 6. Round Southampton FC - Preston North End 3:3
1931/1932 2. Round Preston North End - Southampton FC 2:1
1930/1931 5. Round Southampton FC - Preston North End 2:1
1930/1931 1. Round Preston North End - Southampton FC 5:0
1929/1930 8. Round Preston North End - Southampton FC 1:1
1929/1930 4. Round Southampton FC - Preston North End 1:2
1928/1929 6. Round Preston North End - Southampton FC 0:1
1928/1929 2. Round Southampton FC - Preston North End 4:0
1927/1928 9. Round Preston North End - Southampton FC 1:2
1927/1928 5. Round Southampton FC - Preston North End 0:0
1926/1927 7. Round Preston North End - Southampton FC 1:0
1926/1927 2. Round Southampton FC - Preston North End 1:1
1925/1926 8. Round Southampton FC - Preston North End 2:0
1925/1926 3. Round Preston North End - Southampton FC 2:2
FA Cup
1978/1979 4. Round Preston North End - Southampton FC 0:1
League Cup
2011/2012 3. Round Southampton FC - Preston North End 2:1 (1:0)

For games that were decided on penalties the score after 120 minutes will be included in the ranking