Primera División   M. W D L goals
  at home 25 14 6 5 54 : 31
  Away 26 4 7 15 25 : 37
  51 18 13 20 79 : 68
Copa MX   M. W D L goals
  at home 1 1 0 0 4 : 2
  Away 1 0 0 1 1 : 2
  2 1 0 1 5 : 4
overall   M. W D L goals
  at home 26 15 6 5 58 : 33
  Away 27 4 7 16 26 : 39
  Neutral Place 0 0 0 0 0 : 0
  53 19 13 21 84 : 72
Primera División
2023/2024 Clausura 7. Round Pumas UNAM - Santos Laguna 3:0 (2:0)
2023/2024 Apertura 7. Round Santos Laguna - Pumas UNAM 2:1 (2:1)
2022/2023 Clausura 2. Round Santos Laguna - Pumas UNAM 3:0 (1:0)
2022/2023 Apertura 10. Round Pumas UNAM - Santos Laguna 1:5 (0:3)
2021/2022 Clausura 8. Round Santos Laguna - Pumas UNAM 3:2 (1:1)
2021/2022 Apertura 11. Round Pumas UNAM - Santos Laguna 0:3 (0:1)
2020/2021 Clausura 9. Round Pumas UNAM - Santos Laguna 1:0 (0:0)
2020/2021 Apertura 9. Round Santos Laguna - Pumas UNAM 1:2 (0:1)
2019/2020 Clausura 4. Round Santos Laguna - Pumas UNAM 1:1 (0:0)
2019/2020 Apertura 12. Round Pumas UNAM - Santos Laguna 2:0 (0:0)
2018/2019 Clausura 17. Round Santos Laguna - Pumas UNAM 5:2 (3:1)
2018/2019 Apertura 17. Round Pumas UNAM - Santos Laguna 1:1 (0:1)
2017/2018 Clausura 16. Round Santos Laguna - Pumas UNAM 1:2 (0:2)
2017/2018 Apertura 16. Round Pumas UNAM - Santos Laguna 2:2 (0:0)
2016/2017 Clausura 9. Round Pumas UNAM - Santos Laguna 2:1 (0:0)
2016/2017 Apertura 9. Round Santos Laguna - Pumas UNAM 3:1 (1:0)
2015/2016 Clausura 7. Round Pumas UNAM - Santos Laguna 1:1 (1:1)
2015/2016 Apertura 7. Round Santos Laguna - Pumas UNAM 3:4 (2:3)
2014/2015 Clausura 14. Round Pumas UNAM - Santos Laguna 1:0 (1:0)
2014/2015 Apertura 14. Round Santos Laguna - Pumas UNAM 1:1 (0:0)
2013/2014 Clausura 13. Round Santos Laguna - Pumas UNAM 2:1 (1:1)
2013/2014 Apertura 13. Round Pumas UNAM - Santos Laguna 0:1 (0:0)
2012/2013 Clausura 5. Round Pumas UNAM - Santos Laguna 0:0 (0:0)
2012/2013 Apertura 5. Round Santos Laguna - Pumas UNAM 1:2 (0:1)
2011/2012 Clausura 5. Round Santos Laguna - Pumas UNAM 2:1 (1:0)
2011/2012 Apertura 5. Round Pumas UNAM - Santos Laguna 1:1 (0:0)
2010/2011 Clausura 2. Round Pumas UNAM - Santos Laguna 2:0 (0:0)
2010/2011 Apertura 2. Round Santos Laguna - Pumas UNAM 4:0 (1:0)
2009/2010 Clausura Playoffs Quarter-finals Pumas UNAM - Santos Laguna 1:0 (0:0)
2009/2010 Clausura Playoffs Quarter-finals Santos Laguna - Pumas UNAM 2:0 (1:0)
2009/2010 Clausura 14. Round Pumas UNAM - Santos Laguna 1:0 (0:0)
2009/2010 Apertura 14. Round Santos Laguna - Pumas UNAM 1:1 (0:1)
2008/2009 Clausura 2. Round Pumas UNAM - Santos Laguna 1:0 (1:0)
2008/2009 Apertura 2. Round Santos Laguna - Pumas UNAM 1:1 (0:1)
2007/2008 Clausura 11. Round Pumas UNAM - Santos Laguna 1:1 (1:1)
2007/2008 Apertura Playoffs Semi-finals Santos Laguna - Pumas UNAM 4:2 (2:1)
2007/2008 Apertura Playoffs Semi-finals Pumas UNAM - Santos Laguna 3:0 (1:0)
2007/2008 Apertura 11. Round Santos Laguna - Pumas UNAM 3:2 (1:1)
2006/2007 Clausura 5. Round Pumas UNAM - Santos Laguna 2:1 (1:1)
2006/2007 Apertura 5. Round Santos Laguna - Pumas UNAM 1:1 (1:0)
2005/2006 Clausura 1. Round Pumas UNAM - Santos Laguna 1:0 (0:0)
2005/2006 Apertura 1. Round Santos Laguna - Pumas UNAM 1:2 (0:1)
2004/2005 Clausura 11. Round Santos Laguna - Pumas UNAM 1:1 (1:0)
2004/2005 Apertura 11. Round Pumas UNAM - Santos Laguna 2:1 (2:1)
2003/2004 Clausura 4. Round Pumas UNAM - Santos Laguna 3:2 (2:0)
2003/2004 Apertura 4. Round Santos Laguna - Pumas UNAM 3:0 (1:0)
2002/2003 Clausura 16. Round Santos Laguna - Pumas UNAM 4:1 (1:0)
2002/2003 Apertura 16. Round Pumas UNAM - Santos Laguna 1:0 (0:0)
2001/2002 Verano 5. Round Pumas UNAM - Santos Laguna 3:4 (1:2)
2001/2002 Invierno 5. Round Santos Laguna - Pumas UNAM 1:0 (0:0)
2000/2001 Verano 4. Round Pumas UNAM - Santos Laguna 1:1
Copa MX
2019/2020 Round of 16 Pumas UNAM - Santos Laguna 2:1 (1:1)
2019/2020 Round of 16 Santos Laguna - Pumas UNAM 4:2 (1:0)

For games that were decided on penalties the score after 120 minutes will be included in the ranking