12. Round | 14/10/2021 | Cancún FC | - | Atlético Morelia | 0:1 | ||||
13. Round | 20/10/2021 | Pumas Tabasco | - | Cancún FC | 0:0 | ||||
14. Round | 27/10/2021 | Cancún FC | - | Cimarrones de Sonora | 2:2 | ||||
15. Round | 02/11/2021 | Coyotes de Tlaxcala | - | Cancún FC | 3:1 | ||||
16. Round | 10/11/2021 | Cancún FC | - | Alebrijes de Oaxaca | 1:2 | ||||
17. Round | 17/11/2021 | Club Celaya | - | Cancún FC | 3:1 |