1. Round | 25/07/2021 | Independiente del Valle | - | Orense SC | 3:2 | ||||
2. Round | 01/08/2021 | Orense SC | - | Delfín SC | 2:2 | ||||
3. Round | 08/08/2021 | Aucas | - | Orense SC | 0:0 | ||||
5. Round | 22/08/2021 | Orense SC | - | Deportivo Cuenca | 1:1 | ||||
6. Round | 28/08/2021 | Manta | - | Orense SC | 0:0 | ||||
7. Round | 18/09/2021 | Orense SC | - | Guayaquil City | 2:0 | ||||
8. Round | 25/09/2021 | Mushuc Runa | - | Orense SC | 0:0 | ||||
9. Round | 02/10/2021 | Orense SC | - | Macará | 2:1 |