| 1. Round | 30/10/2021 | Portuguesa FC | - | Aragua FC | 1:1 | ||||
| 2. Round | 02/11/2021 | Metropolitanos FC | - | Portuguesa FC | 1:0 |  |
|||
| 7. Round | 23/11/2021 | Portuguesa FC | - | Metropolitanos FC | 1:1 | ||||
| 9. Round | 30/11/2021 | Academia Puerto Cabello | - | Portuguesa FC | 0:0 | |
|||
| 10. Round | 04/12/2021 | Portuguesa FC | - | Hermanos Colmenarez | 3:0 |
Venezuela