2. Round | 16/01/2022 | CF Pachuca | - | Deportivo Guadalajara | 2:1 | ||||
3. Round | 22/01/2022 | Deportivo Guadalajara | - | Gallos Blancos | 1:1 | ||||
4. Round | 10/02/2022 | FC Juárez | - | Deportivo Guadalajara | 1:3 | ||||
5. Round | 12/02/2022 | Deportivo Guadalajara | - | UANL Tigres | 1:3 | ||||
8. Round | 03/03/2022 | Atlético San Luis | - | Deportivo Guadalajara | 2:2 | ||||
9. Round | 06/03/2022 | Deportivo Guadalajara | - | Santos Laguna | 1:0 | ||||
10. Round | 13/03/2022 | Deportivo Guadalajara | - | CF América | 0:0 | ||||
11. Round | 21/03/2022 | Atlas Guadalajara | - | Deportivo Guadalajara | 1:1 | ||||
13. Round | 10/04/2022 | Deportivo Toluca | - | Deportivo Guadalajara | 1:1 | ||||
14. Round | 17/04/2022 | Cruz Azul | - | Deportivo Guadalajara | 0:1 | ||||
15. Round | 20/04/2022 | Deportivo Guadalajara | - | Club Tijuana | 2:1 | ||||
16. Round | 24/04/2022 | Deportivo Guadalajara | - | Pumas UNAM | 3:1 | ||||
17. Round | 30/04/2022 | Club Necaxa | - | Deportivo Guadalajara | 0:1 |