| 1. Round | 30/01/2010 | Tacuary | - | Cerro Porteño | 1:2 | ||||
| 2. Round | 07/02/2010 | Club Olimpia | - | Tacuary | 3:2 |  |
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| 4. Round | 17/02/2010 | Guaraní | - | Tacuary | 5:2 | ||||
| 5. Round | 21/02/2010 | Tacuary | - | Club Rubio Ñu | 0:1 | ||||
| 6. Round | 28/02/2010 | Tacuary | - | Sportivo Trinidense | 2:0 | |
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| 7. Round | 06/03/2010 | Sportivo Luqueño | - | Tacuary | 3:3 | ||||
| 8. Round | 12/03/2010 | Tacuary | - | Sol de América | 1:1 |  |
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| 10. Round | 21/03/2010 | Tacuary | - | 3 de Febrero | 3:0 | |
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| 9. Round | 24/03/2010 | Club Nacional | - | Tacuary | 4:0 | ||||
| 11. Round | 28/03/2010 | Sport Colombia | - | Tacuary | 0:0 | ||||
| 12. Round | 04/04/2010 | Cerro Porteño | - | Tacuary | 1:0 | ||||
| 13. Round | 10/04/2010 | Tacuary | - | Club Olimpia | 0:4 | ||||
| 15. Round | 18/04/2010 | Tacuary | - | Guaraní | 1:4 | ||||
| 16. Round | 25/04/2010 | Club Rubio Ñu | - | Tacuary | 3:1 | ||||
| 17. Round | 02/05/2010 | Sportivo Trinidense | - | Tacuary | 0:1 | |
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| 18. Round | 08/05/2010 | Tacuary | - | Sportivo Luqueño | 1:2 | ||||
| 19. Round | 12/05/2010 | Sol de América | - | Tacuary | 1:0 |
Paraguay