2. Round | 10/06/2021 | Rocha | - | Central Español | 3:2 | ||||
3. Round | 16/06/2021 | Central Español | - | CA Cerro | 3:2 | ||||
4. Round | 26/06/2021 | Defensor Sporting | - | Central Español | 4:0 | ||||
6. Round | 07/07/2021 | Central Español | - | Atenas | 0:3 | ||||
7. Round | 15/07/2021 | Racing | - | Central Español | 1:0 | ||||
12. Round | 15/09/2021 | Danubio | - | Central Español | 1:1 | ||||
14. Round | 28/09/2021 | CA Cerro | - | Central Español | 0:0 | ||||
16. Round | 11/10/2021 | Central Español | - | Albion | 3:4 | ||||
19. Round | 02/11/2021 | Villa Teresa | - | Central Español | 1:2 | ||||
21. Round | 18/11/2021 | Uruguay Montevideo | - | Central Español | 0:3 | ||||
22. Round | 25/11/2021 | Central Español | - | Rampla Juniors | 3:0 |