12. Round | 31/07/2021 | Real Santa Cruz | - | Independiente Petrolero | 2:0 | ||||
14. Round | 07/08/2021 | Real Santa Cruz | - | Oriente Petrolero | 0:0 | ||||
15. Round | 15/08/2021 | The Strongest | - | Real Santa Cruz | 1:2 | ||||
16. Round | 20/08/2021 | Jorge Wilstermann | - | Real Santa Cruz | 5:1 | ||||
17. Round | 23/08/2021 | Real Santa Cruz | - | Atlético Palmaflor | 1:0 | ||||
18. Round | 14/09/2021 | Always Ready | - | Real Santa Cruz | 4:0 | ||||
19. Round | 18/09/2021 | Real Santa Cruz | - | Royal Pari | 2:1 | ||||
20. Round | 22/09/2021 | Real Potosí | - | Real Santa Cruz | 3:0 | ||||
21. Round | 27/09/2021 | Real Santa Cruz | - | CD Guabirá | 3:0 | ||||
22. Round | 18/10/2021 | Blooming | - | Real Santa Cruz | 3:1 | ||||
23. Round | 25/10/2021 | Real Santa Cruz | - | Bolívar | 0:3 | ||||
25. Round | 01/11/2021 | Real Santa Cruz | - | Real Tomayapo | 2:0 | ||||
26. Round | 22/11/2021 | San José | - | Real Santa Cruz | 1:2 | ||||
27. Round | 27/11/2021 | Independiente Petrolero | - | Real Santa Cruz | 2:1 | ||||
28. Round | 01/12/2021 | Real Santa Cruz | - | Nacional Potosí | 1:1 | ||||
29. Round | 05/12/2021 | Oriente Petrolero | - | Real Santa Cruz | 2:0 |