1. Round | 06/02/2022 | Cerro Porteño | - | Sportivo Ameliano | 3:2 | ||||
2. Round | 13/02/2022 | Club Nacional | - | Cerro Porteño | 2:3 | ||||
9. Round | 09/04/2022 | General Caballero DJLM | - | Cerro Porteño | 0:0 | ||||
10. Round | 17/04/2022 | Cerro Porteño | - | Libertad | 4:0 | ||||
11. Round | 21/04/2022 | Tacuary | - | Cerro Porteño | 2:0 | ||||
14. Round | 09/05/2022 | Guaraní | - | Cerro Porteño | 1:2 | ||||
15. Round | 12/05/2022 | Cerro Porteño | - | Guaireña FC | 0:0 | ||||
17. Round | 22/05/2022 | Club Olimpia | - | Cerro Porteño | 0:4 | ||||
19. Round | 18/06/2022 | 12 de Octubre de Itauguá | - | Cerro Porteño | 0:1 | ||||
20. Round | 21/06/2022 | Cerro Porteño | - | General Caballero DJLM | 3:1 | ||||
21. Round | 26/06/2022 | Libertad | - | Cerro Porteño | 1:0 |