1. Round | 25/07/2021 | Deportivo Guadalajara | - | Atlético San Luis | 1:2 | ||||
2. Round | 31/07/2021 | Puebla FC | - | Deportivo Guadalajara | 0:2 | ||||
5. Round | 19/08/2021 | Deportivo Guadalajara | - | Club León | 0:3 | ||||
9. Round | 19/09/2021 | Deportivo Guadalajara | - | CF Pachuca | 1:0 | ||||
10. Round | 26/09/2021 | CF América | - | Deportivo Guadalajara | 0:0 | ||||
11. Round | 30/09/2021 | Gallos Blancos | - | Deportivo Guadalajara | 1:0 | ||||
12. Round | 03/10/2021 | Deportivo Guadalajara | - | Atlas Guadalajara | 0:1 | ||||
14. Round | 21/10/2021 | Club Tijuana | - | Deportivo Guadalajara | 0:0 | ||||
16. Round | 31/10/2021 | UANL Tigres | - | Deportivo Guadalajara | 2:1 | ||||
17. Round | 06/11/2021 | Mazatlán FC | - | Deportivo Guadalajara | 0:1 |