1. Round | 24/07/2021 | FK Pardubice | - | MFK Karviná | 2:2 | ||||
2. Round | 31/07/2021 | MFK Karviná | - | FC Hradec Králové | 1:1 | ||||
3. Round | 07/08/2021 | AC Sparta Praha | - | MFK Karviná | 2:0 | ||||
5. Round | 22/08/2021 | Viktoria Plzeň | - | MFK Karviná | 2:0 | ||||
6. Round | 29/08/2021 | MFK Karviná | - | Slavia Praha | 3:3 | ||||
7. Round | 12/09/2021 | FK Jablonec | - | MFK Karviná | 1:0 | ||||
8. Round | 19/09/2021 | MFK Karviná | - | FK Teplice | 1:1 | ||||
9. Round | 25/09/2021 | Dynamo České Budějovice | - | MFK Karviná | 3:1 | ||||
10. Round | 03/10/2021 | MFK Karviná | - | FK Mladá Boleslav | 0:1 | ||||
11. Round | 17/10/2021 | Sigma Olomouc | - | MFK Karviná | 2:0 | ||||
14. Round | 07/11/2021 | MFK Karviná | - | 1. FC Slovácko | 2:2 | ||||
15. Round | 21/11/2021 | MFK Karviná | - | Slovan Liberec | 1:2 | ||||
12. Round | 24/11/2021 | MFK Karviná | - | Baník Ostrava | 1:2 | ||||
16. Round | 28/11/2021 | FC Hradec Králové | - | MFK Karviná | 1:0 | ||||
13. Round | 01/12/2021 | Bohemians Praha 1905 | - | MFK Karviná | 3:0 | ||||
17. Round | 04/12/2021 | MFK Karviná | - | AC Sparta Praha | 1:2 | ||||
18. Round | 11/12/2021 | FC Fastav Zlín | - | MFK Karviná | 2:1 | ||||
30. Round | 20/04/2022 | MFK Karviná | - | FK Pardubice | 3:2 |