15. Round | 28/01/2022 | US Lecce [Youth] | - | Sampdoria [Youth] | 1:3 | ||||
16. Round | 01/02/2022 | AS Roma [Youth] | - | US Lecce [Youth] | 2:2 | ||||
17. Round | 06/02/2022 | Torino FC [Youth] | - | US Lecce [Youth] | 1:1 | ||||
18. Round | 13/02/2022 | US Lecce [Youth] | - | Cagliari Calcio [Youth] | 1:3 | ||||
19. Round | 17/02/2022 | Bologna FC [Youth] | - | US Lecce [Youth] | 2:0 | ||||
20. Round | 21/02/2022 | US Lecce [Youth] | - | Hellas Verona [Youth] | 3:4 | ||||
21. Round | 27/02/2022 | Genoa CFC [Youth] | - | US Lecce [Youth] | 0:1 | ||||
22. Round | 05/03/2022 | US Lecce [Youth] | - | Atalanta [Youth] | 2:1 | ||||
23. Round | 09/03/2022 | AC Milan [Youth] | - | US Lecce [Youth] | 1:0 | ||||
24. Round | 14/03/2022 | US Lecce [Youth] | - | Sassuolo Calcio [Youth] | 2:1 |